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What the FDA labels say about taking them together

Calcipotriene and calcium chloride

Calcium chloride's FDA label of February 2, 2026 names calcipotriene in its drug interactions section; the calcipotriene labels PlainMeds reads (3) do not name calcium chloride. The calcium chloride label: “Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia.”

Check it at the source: the calcipotriene FDA label on DailyMed (effective August 7, 2020, Prasco Laboratories); the calcium chloride FDA label on DailyMed (effective February 2, 2026, Hospira, Inc.).

What does the calcipotriene label say about calcium chloride?

Calcipotriene's label (effective August 7, 2020) and its 2 other brand-application labels do not name calcium chloride in these sections. A label lists what its studies and reports found; it is not a complete list.

Source: FDA drug label (calcipotriene), NDA020273 (Leo Pharma As), as published by Prasco Laboratories, effective August 7, 2020 (SPL set fe7cd92a-f066-4c4a-80c8-e3f929ad4181), via openFDA; the full label on DailyMed

What does the calcium chloride label say about calcipotriene?

Calcium chloride label, drug interactions

Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D).

Source: FDA drug label (Calcium Chloride), Hospira, Inc., effective February 2, 2026 (SPL set c4c65e48-85f8-4dcf-6281-06e40959cc79), via openFDA; the full label on DailyMed

These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.

Both medicines on the record

6Calcipotriene generic labelers
13Calcium chloride generic labelers
CalcipotrieneCalcium chloride
Labeled forPsoriasisn/a
Boxed warningNoNo
Pharmacy cost (NADAC)$1.05 per gram 0.005% creamn/a
Shortage nowNo current entryA presentation being discontinued

Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)

What next?