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What the label lists and what reports show

Calcium chloride side effects

Calcium chloride's FDA label lists its adverse reactions in its own words. FAERS holds 3,072 reports naming it through July 30, 2026; the reaction reported most often, leaving out the conditions it is used for, product-use terms and outcomes, is pain (432 reports).

  • Generic listed
  • A presentation discontinued

Check it at the source: the calcium chloride FDA label on DailyMed (effective February 2, 2026, Hospira, Inc.); the FDA FAERS public dashboard.

What does the label list?

From the label: adverse reactions

The following serious adverse reactions are also described elsewhere in the labeling: • End-Organ Damage due to Intravascular Ceftriaxone-Calcium Precipitates [see Warnings and Precautions (5.1) ] • Hypotension, Bradycardia, Arrhythmias, and Syncope with Rapid Administration [see Warnings and Precautions (5.2) ] • Arrhythmias with Concomitant Digoxin Use [see Warnings and Precautions (5.3) ] • Tissue Necrosis and Calcinosis [see Warnings and Precautions (5.4) ] • Aluminum toxicity [see Warnings and Precautions (5.5) ] The following adverse reactions have been identified in literature and postmarketing reports of calcium chloride. …

Source: FDA drug label, Hospira, Inc., effective February 2, 2026 (SPL set c4c65e48-85f8-4dcf-6281-06e40959cc79), via openFDA; the full label on DailyMed

What do FAERS reports show?

3,072 reports list calcium chloride among the medicines taken, each a report of something that happened, not proof the medicine caused it; 720 are coded as a death and 1,387 as a hospital stay. Counts follow how widely a medicine is used and watched, and they are not a measure of how risky it is. Of the 21 reactions below, 1 is named by the same term (in US spelling) in the label's adverse reactions, warnings or patient leaflet; a reaction the label does not name may still be there under another word, and a report does not show that the medicine caused it.

Reports received each year

The 25 most reported reactions

  • Pain432
  • Injury411
  • Drug Ineffective (a use or a product term, not a reaction)407
  • Nausea340
  • Off Label Use (a use or a product term, not a reaction)317
  • Anxiety297
  • Renal Failure279
  • Pyrexia271
  • Hypotension (named in the label)247
  • Dyspnoea241
  • Pneumonia219
  • Condition Aggravated (a use or a product term, not a reaction)218
  • Pemphigus218
  • Joint Swelling214
  • Oedema213
  • Unevaluable Event209
  • Vomiting206
  • Pain In Extremity204
  • Death (an outcome recorded in the report)200
  • Fatigue200
  • Urticaria200
  • Sleep Disorder199
  • Hypertension193
  • Mobility Decreased192
  • Type 2 Diabetes Mellitus191

Source: FDA Adverse Event Reporting System (FAERS) via openFDA, reports through July 30, 2026; reactions as MedDRA preferred terms

What next?

Calcium chloride: the full record
label, generics, price, shortages, recalls
Side effects hub
the most reported medicines and reactions