What the FDA labels say about taking them together
Calcium chloride and lithium
Calcium chloride's FDA label of February 2, 2026 names lithium in its drug interactions section; the lithium labels PlainMeds reads (4) do not name calcium chloride. The calcium chloride label: “Increase the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia.”
Check it at the source: the calcium chloride FDA label on DailyMed (effective February 2, 2026, Hospira, Inc.); the lithium FDA label on DailyMed (effective December 23, 2025, Glenmark Pharmaceuticals Inc., USA).
What does the calcium chloride label say about lithium?
Calcium chloride label, drug interactionsIncrease the Risk of Hypercalcemia Increase frequency of monitoring of calcium concentrations in patients taking concomitant Calcium Chloride Injection and other drugs that increase the risk of hypercalcemia (e.g., calcipotriene, estrogen, lithium, parathyroid hormone, teriparatide, thiazide diuretics, Vitamin A, and Vitamin D).
Source: FDA drug label (Calcium Chloride), Hospira, Inc., effective February 2, 2026 (SPL set c4c65e48-85f8-4dcf-6281-06e40959cc79), via openFDA; the full label on DailyMed
What does the lithium label say about calcium chloride?
Lithium's label (effective December 23, 2025) and its 3 other brand-application labels do not name calcium chloride in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Lithium Carbonate), Glenmark Pharmaceuticals Inc., USA, effective December 23, 2025 (SPL set 63b3790f-a9b5-47f4-bae1-ddf8b43c13c1), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Calcium chloride | Lithium | |
|---|---|---|
| Labeled for | n/a | Bipolar disorder |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | n/a | $0.104 per capsule 300 mg capsule |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once