What the FDA labels say about taking them together
Calcium chloride and digoxin
Calcium chloride's FDA label of February 2, 2026 names digoxin in its drug interactions section; the digoxin labels PlainMeds reads (3) do not name calcium chloride. The calcium chloride label: “Avoid the concomitant use of Calcium Chloride Injection with digoxin.”
Check it at the source: the calcium chloride FDA label on DailyMed (effective February 2, 2026, Hospira, Inc.); the digoxin FDA label on DailyMed (effective December 5, 2024, Advanz Pharma (US) Corp.).
What does the calcium chloride label say about digoxin?
Calcium chloride label, drug interactionsAvoid the concomitant use of Calcium Chloride Injection with digoxin.
Calcium chloride label, warnings and precautionsArrhythmias with Concomitant Digoxin Use: Avoid use of Calcium Chloride Injection in patients receiving digoxin.
Source: FDA drug label (Calcium Chloride), Hospira, Inc., effective February 2, 2026 (SPL set c4c65e48-85f8-4dcf-6281-06e40959cc79), via openFDA; the full label on DailyMed
What does the digoxin label say about calcium chloride?
Digoxin's label (effective December 5, 2024) and its 2 other brand-application labels do not name calcium chloride in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (LANOXIN), Advanz Pharma (US) Corp., effective December 5, 2024 (SPL set d91e3646-4c63-4512-ab22-db39c085c4dc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Calcium chloride | Digoxin | |
|---|---|---|
| Labeled for | n/a | Heart failure, Atrial fibrillation |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $0.133 per tablet 125 mcg tablet |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once