What the FDA labels say about taking them together
Calcium chloride and ceftriaxone
Calcium chloride's FDA label of February 2, 2026 names ceftriaxone in its contraindications section; the ceftriaxone labels PlainMeds reads (2) do not name calcium chloride. The calcium chloride label: “End-Organ Damage due to Intravascular Ceftriaxone-Calcium Precipitates: Calcium Chloride Injection is contraindicated in newborns (up to 28 days of age) if they require ceftriaxone intravenous treatment.”
Check it at the source: the calcium chloride FDA label on DailyMed (effective February 2, 2026, Hospira, Inc.); the ceftriaxone FDA label on DailyMed (effective February 4, 2026, Qilu Pharmaceutical Co., Ltd.).
What does the calcium chloride label say about ceftriaxone?
Calcium chloride label, contraindicationsPatients with asystole and electromechanical dissociation Newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment because of the risk of precipitation of ceftriaxone-calcium, regardless of whether these products would be received at different times or through separate intravenous lines [see Warnings and Precautions (5.1) ].
Calcium chloride label, warnings and precautionsEnd-Organ Damage due to Intravascular Ceftriaxone-Calcium Precipitates: Calcium Chloride Injection is contraindicated in newborns (up to 28 days of age) if they require (or are expected to require) ceftriaxone intravenous treatment.
Source: FDA drug label (Calcium Chloride), Hospira, Inc., effective February 2, 2026 (SPL set c4c65e48-85f8-4dcf-6281-06e40959cc79), via openFDA; the full label on DailyMed
What does the ceftriaxone label say about calcium chloride?
Ceftriaxone's label (effective February 4, 2026) and its 1 other brand-application label do not name calcium chloride in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Ceftriaxone Sodium), Qilu Pharmaceutical Co., Ltd., effective February 4, 2026 (SPL set 4cdf0743-c62b-4969-b9c9-4c6400644f6c), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Calcium chloride | Ceftriaxone | |
|---|---|---|
| Labeled for | n/a | Urinary tract infections, Bacterial infections |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | n/a | $1.44 per vial 1 g vial |
| Shortage now | A presentation being discontinued | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once