tranylcypromine vs vortioxetine
Side-by-side comparison of tranylcypromine and vortioxetine. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
[see Dosage and Administration (2.4) , Contraindications (4) , Warnings and Precautions (5.2) ] Examples selegiline, tranylcypromine, isocarboxazid, phenelzine, linezolid, methylene blue Other Serotonergic Drugs Clinical Impact Concomitant use of TRINTELLIX with other serotonergic drugs increases the risk of serotonin syndrome.
Recommendation: This combination should be avoided. Talk to your doctor about the safe amount of time to wait when switching between these medications.
Parnate
Trintellix
Tranylcypromine (Parnate) is a medicine used to treat major depression in adults. It is used when other antidepressants have not worked well enough.
Trintellix is a medicine used to treat major depressive disorder (MDD) in adults. It helps to improve mood and reduce symptoms of depression.
Tranylcypromine is used to treat major depressive disorder (MDD) in adults. You should only use it if other antidepressants haven't helped. It is not for the first treatment of depression because it can cause serious side effects and has many drug and food interactions.
Trintellix is used to treat major depressive disorder (MDD) in adults. MDD can cause you to feel sad, hopeless, and lose interest in things. This medicine can help improve your mood and reduce these symptoms.
Tranylcypromine belongs to a class of drugs called MAO inhibitors. It works by increasing the levels of certain chemicals in your brain. These chemicals can help improve your mood.
Trintellix affects the levels of certain chemicals in the brain. These chemicals, like serotonin, help regulate mood. By changing the balance of these chemicals, Trintellix can help improve symptoms of depression.
- • Dry mouth
- • Dizziness
- • Trouble sleeping
- • Feeling sleepy
- • Headache
- • Nausea
- • Constipation
- • Vomiting
- Interaction between medicines 68
- Feeling sad or hopeless 36
- Too much serotonin in the body 27
- Head pain 24
- High blood pressure 24
- Feeling sick to your stomach 2,185
- Feeling very tired 1,179
- Pain in your head 1,027
- Feeling worried or nervous 996
- Throwing up 989
Tranylcypromine can increase the risk of suicidal thoughts and behaviors in young adults. It can also cause a dangerous increase in blood pressure if you eat foods high in tyramine or take certain medicines. Make sure to follow all food and drug restrictions.
Antidepressants may increase the risk of suicidal thoughts and behaviors in young adults. Your doctor will monitor you closely for worsening depression or suicidal thoughts, especially when you first start taking Trintellix or when your dose is changed. Trintellix is not approved for use in children.
There is limited information about the safety of tranylcypromine during pregnancy. Talk to your doctor if you are pregnant or plan to become pregnant. It is not recommended to breastfeed while taking this medicine because it can harm the baby.
Tell your doctor if you are pregnant or plan to become pregnant. Taking Trintellix in the last 3 months of pregnancy may cause problems in the newborn. There is a pregnancy registry to monitor outcomes in women exposed to antidepressants during pregnancy. You can register by calling 1-844-405-6185.
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How to Read This tranylcypromine vs vortioxetine Comparison
tranylcypromine is classified in the Monoamine Oxidase Inhibitor (MAOI) drug class, while vortioxetine sits within the Serotonin Modulator class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, tranylcypromine has 179 submissions while vortioxetine has 6,376. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to these medications both raise serotonin levels in your body. combining them can lead to a serious reaction known as serotonin syndrome.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between tranylcypromine and vortioxetine - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.