Rosiglitazone and Metformin Interaction
Drug interaction information between Rosiglitazone and Metformin.
Rosiglitazone and Metformin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rosiglitazone and Metformin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Certain drugs use the same pathway to leave the body through the kidneys, which can cause metformin levels to build up.
What To Do
Your doctor should monitor you carefully and may need to adjust your medication doses if you take these together.
FDA Label Information
[See Clinical Pharmacology (12.4).] 7.2 Cationic Drugs Although drug interactions for metformin with cationic drugs (e.g., amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, and vancomycin) remain theoretical (except for cimetidine), careful patient monitoring and dose adjustment of AVANDAMET and/or the interfering drug is recommended in patients who are taking cationic medications that are excreted via the proximal renal tubular secretory system.
Rosiglitazone Also Interacts With
- Clarithromycin major
- Morphine minor
- Vancomycin minor
- Amiloride minor
- Digoxin minor
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Ertugliflozin moderate
Frequently Asked Questions
Can I take Rosiglitazone and Metformin together?
This is a minor interaction. Your doctor should monitor you carefully and may need to adjust your medication doses if you take these together.
How serious is the interaction between Rosiglitazone and Metformin?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Rosiglitazone and Metformin interact?
Certain drugs use the same pathway to leave the body through the kidneys, which can cause metformin levels to build up.
Understanding the Rosiglitazone and Metformin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Rosiglitazone belongs to the Thiazolidinedione class and Metformin belongs to the Biguanide class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Certain drugs use the same pathway to leave the body through the kidneys, which can cause metformin levels to build up. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Rosiglitazone has 12 total documented interactions on file in this dataset, and Metformin has 27. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor you carefully and may need to adjust your medication doses if you take these together. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Rosiglitazone or Metformin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.