Valsartan and Glecaprevir/Pibrentasvir Interaction
Drug interaction information between Valsartan and Glecaprevir/Pibrentasvir.
Valsartan and Glecaprevir/Pibrentasvir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Valsartan and Glecaprevir/Pibrentasvir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
There is no significant interaction between these two drugs that would affect how they work.
FDA Label Information
7.5 Drugs with No Observed Clinically Significant Interactions with MAVYRET No dose adjustment is required when MAVYRET is coadministered with the following medications: abacavir, amlodipine, caffeine, dextromethorphan, dolutegravir, elvitegravir/ cobicistat, emtricitabine, ethinyl estradiol of 20 mcg or less, felodipine, lamivudine, lamotrigine, losartan, midazolam, norethindrone or other progestin-only contraceptives, omeprazole, raltegravir, rilpivirine, sofosbuvir, tacrolimus, tenofovir alafenamide, tenofovir disoproxil fumarate, tolbutamide, and valsartan.
Valsartan Also Interacts With
- Sacubitril/Valsartan major
- Aliskiren major
- Lithium moderate
- Spironolactone minor
- Amiloride minor
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Frequently Asked Questions
What SPL severity band is on file for Valsartan + Glecaprevir/Pibrentasvir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Glecaprevir/Pibrentasvir has 38 labeled pairs on file vs Valsartan's 8. In the minor band specifically: Valsartan has 5 (also Spironolactone, Amiloride, Amlodipine/Valsartan, Dapagliflozin); Glecaprevir/Pibrentasvir has 26 (also Atorvastatin, Amlodipine, Losartan, Omeprazole).
What mechanism field is on file for Valsartan and Glecaprevir/Pibrentasvir?
There is no significant interaction between these two drugs that would affect how they work.
Glecaprevir/Pibrentasvir carries more major-labeled pairs than Valsartan
SPL source-record counts only. This page's band is minor · classes on file: Valsartan (Angiotensin II Receptor Blocker (ARB)); Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)).
Glecaprevir/Pibrentasvir has 3 major-labeled pairs vs Valsartan's 2. This page itself is in the minor band, not the major band.
2 major · 1 moderate · 5 minor · 8 total
- Other minor peers for Valsartan
- Spironolactone
- Amiloride
- Amlodipine/Valsartan
- Dapagliflozin
3 major · 9 moderate · 26 minor · 38 total
- Other minor peers for Glecaprevir/Pibrentasvir
- Atorvastatin
- Amlodipine
- Losartan
- Omeprazole
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.