Valsartan and Amiloride Interaction
Drug interaction information between Valsartan and Amiloride.
Valsartan and Amiloride have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Valsartan and Amiloride. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These medications both prevent the kidneys from removing potassium, which can cause potassium to build up to unsafe levels.
What To Do
Have your blood potassium levels checked frequently by your healthcare provider.
FDA Label Information
7.2 Potassium-Sparing Diuretics As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium [see Warnings and Precautions (5.5)] .
Valsartan Also Interacts With
- Sacubitril/Valsartan major
- Aliskiren major
- Lithium moderate
- Spironolactone minor
- Amlodipine/Valsartan minor
Amiloride Also Interacts With
- Potassium Chloride major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine/Benazepril moderate
- Benazepril moderate
Frequently Asked Questions
Can I take Valsartan and Amiloride together?
This is a minor interaction. Have your blood potassium levels checked frequently by your healthcare provider.
How serious is the interaction between Valsartan and Amiloride?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Valsartan and Amiloride interact?
These medications both prevent the kidneys from removing potassium, which can cause potassium to build up to unsafe levels.
Understanding the Valsartan and Amiloride Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Valsartan belongs to the Angiotensin II Receptor Blocker (ARB) class and Amiloride belongs to the Potassium-Sparing Diuretic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These medications both prevent the kidneys from removing potassium, which can cause potassium to build up to unsafe levels. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Valsartan has 8 total documented interactions on file in this dataset, and Amiloride has 19. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Have your blood potassium levels checked frequently by your healthcare provider. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Valsartan or Amiloride based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.