Valsartan and Amlodipine/Valsartan Interaction
Drug interaction information between Valsartan and Amlodipine/Valsartan.
Valsartan and Amlodipine/Valsartan have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Valsartan and Amlodipine/Valsartan. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking both of these medications results in a double dose of valsartan. This increases your risk for high potassium levels, kidney damage, and very low blood pressure.
What To Do
Avoid taking these two medications together as they contain the same active ingredient. Your doctor should check your medication list to prevent an accidental overdose.
FDA Label Information
Valsartan Agents Increasing Serum Potassium: Concomitant use of valsartan with other agents that block the renin-angiotensin system, potassium-sparing diuretics (e.g., spironolactone, triamterene, amiloride), potassium supplements, salt substitutes containing potassium or other drugs that may increase potassium levels (e.g., heparin) may lead to increases in serum potassium and in heart failure patients to increases in serum creatinine. Non-Steroidal Anti-Inflammatory (NSAID) Agents Including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors): In patients who are elderly,...
Valsartan Also Interacts With
- Sacubitril/Valsartan major
- Aliskiren major
- Lithium moderate
- Spironolactone minor
- Amiloride minor
Amlodipine/Valsartan Also Interacts With
- Simvastatin major
- Aliskiren major
- Cyclosporine moderate
- Lithium moderate
- Amlodipine minor
Frequently Asked Questions
Can I take Valsartan and Amlodipine/Valsartan together?
This is a minor interaction. Avoid taking these two medications together as they contain the same active ingredient. Your doctor should check your medication list to prevent an accidental overdose.
How serious is the interaction between Valsartan and Amlodipine/Valsartan?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Valsartan and Amlodipine/Valsartan interact?
Taking both of these medications results in a double dose of valsartan. This increases your risk for high potassium levels, kidney damage, and very low blood pressure.
Understanding the Valsartan and Amlodipine/Valsartan Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Valsartan belongs to the Angiotensin II Receptor Blocker (ARB) class and Amlodipine/Valsartan belongs to the CCB / ARB Combination class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking both of these medications results in a double dose of valsartan. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Valsartan has 8 total documented interactions on file in this dataset, and Amlodipine/Valsartan has 14. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Avoid taking these two medications together as they contain the same active ingredient. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Valsartan or Amlodipine/Valsartan based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.