Valproate and Acetaminophen Interaction
Drug interaction information between Valproate and Acetaminophen.
Valproate and Acetaminophen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Valproate and Acetaminophen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These two medicines do not have a significant effect on each other when they are taken at the same time.
FDA Label Information
Drugs for which either no interaction or a likely clinically unimportant interaction has been observed Acetaminophen Valproate had no effect on any of the pharmacokinetic parameters of acetaminophen when it was concurrently administered to three epileptic patients.
Valproate Also Interacts With
- Ranitidine major
- Cimetidine major
- Clarithromycin moderate
- Lidocaine Topical moderate
- Risperidone moderate
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Cidofovir minor
Frequently Asked Questions
What SPL severity band is on file for Valproate + Acetaminophen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Valproate has 41 labeled pairs on file vs Acetaminophen's 23. In the minor band specifically: Valproate has 36 (also Aspirin, Clonazepam, Topiramate, Amitriptyline); Acetaminophen has 21 (also Acetaminophen/Oxycodone, Carbamazepine, Cidofovir, Codeine).
What mechanism field is on file for Valproate and Acetaminophen?
These two medicines do not have a significant effect on each other when they are taken at the same time.
Valproate carries more major-labeled pairs than Acetaminophen
SPL source-record counts only. This page's band is minor · classes on file: Valproate (Anticonvulsant / Mood Stabilizer); Acetaminophen (Analgesic / Antipyretic).
Valproate has 2 major-labeled pairs vs Acetaminophen's 0. This page itself is in the minor band, not the major band.
2 major · 3 moderate · 36 minor · 41 total
- Other minor peers for Valproate
- Aspirin
- Clonazepam
- Topiramate
- Amitriptyline
0 major · 2 moderate · 21 minor · 23 total
- Other minor peers for Acetaminophen
- Acetaminophen/Oxycodone
- Carbamazepine
- Cidofovir
- Codeine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.