Terazosin and Atenolol Interaction
Drug interaction information between Terazosin and Atenolol.
Terazosin and Atenolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Terazosin and Atenolol. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both of these medications work to lower blood pressure. Using them together can cause your blood pressure to drop more than if you took only one.
What To Do
Your doctor might need to adjust your dose. Watch for signs of dizziness or lightheadedness, especially when you first start taking them together.
FDA Label Information
Terazosin has been used concomitantly in at least 50 patients on the following drugs or drug classes: analgesic/anti-inflammatory (e.g., acetaminophen, aspirin, codeine, ibuprofen, indomethacin); antibiotics (e.g., erythromycin, trimethoprim and sulfamethoxazole); anticholinergic/sympathomimetics (e.g., phenylephrine hydrochloride, phenylpropanolamine hydrochloride, pseudoephedrine hydrochloride); antigout (e.g., allopurinol); antihistamines (e.g., chlorpheniramine); cardiovascular agents (e.g., atenolol, hydrochlorothiazide, methyclothiazide, propranolol); corticosteroids;...
Terazosin Also Interacts With
- Hydrochlorothiazide minor
- Ibuprofen minor
- Allopurinol minor
- Aspirin minor
- Acetaminophen minor
Atenolol Also Interacts With
- Aspirin major
- Theophylline major
- Clonidine minor
- Amiodarone minor
- Epinephrine minor
Frequently Asked Questions
Can I take Terazosin and Atenolol together?
This is a minor interaction. Your doctor might need to adjust your dose. Watch for signs of dizziness or lightheadedness, especially when you first start taking them together.
How serious is the interaction between Terazosin and Atenolol?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Terazosin and Atenolol interact?
Both of these medications work to lower blood pressure. Using them together can cause your blood pressure to drop more than if you took only one.
Understanding the Terazosin and Atenolol Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Terazosin belongs to the Alpha-1 Blocker class and Atenolol belongs to the Beta-1 Selective Blocker class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both of these medications work to lower blood pressure. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Terazosin has 15 total documented interactions on file in this dataset, and Atenolol has 14. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor might need to adjust your dose. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Terazosin or Atenolol based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.