Terazosin and Ibuprofen Interaction
Drug interaction information between Terazosin and Ibuprofen.
Terazosin and Ibuprofen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Terazosin and Ibuprofen. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ibuprofen belongs to a class of drugs that can cause the body to retain fluid. This may make blood pressure medications like terazosin less effective.
FDA Label Information
Terazosin has been used concomitantly in at least 50 patients on the following drugs or drug classes: analgesic/anti-inflammatory (e.g., acetaminophen, aspirin, codeine, ibuprofen, indomethacin); antibiotics (e.g., erythromycin, trimethoprim and sulfamethoxazole); anticholinergic/sympathomimetics (e.g., phenylephrine hydrochloride, phenylpropanolamine hydrochloride, pseudoephedrine hydrochloride); antigout (e.g., allopurinol); antihistamines (e.g., chlorpheniramine); cardiovascular agents (e.g., atenolol, hydrochlorothiazide, methyclothiazide, propranolol); corticosteroids;...
Terazosin Also Interacts With
- Hydrochlorothiazide minor
- Allopurinol minor
- Aspirin minor
- Atenolol minor
- Acetaminophen minor
Ibuprofen Also Interacts With
- Heparin moderate
- Warfarin moderate
- Carbamazepine minor
- Digoxin minor
- Fluconazole minor
Frequently Asked Questions
What SPL severity band is on file for Terazosin + Ibuprofen?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Terazosin has 15 labeled pairs on file vs Ibuprofen's 9. In the minor band specifically: Terazosin has 15 (also Hydrochlorothiazide, Allopurinol, Aspirin, Atenolol); Ibuprofen has 7 (also Carbamazepine, Digoxin, Fluconazole, Prenatal Multivitamin).
What mechanism field is on file for Terazosin and Ibuprofen?
Ibuprofen belongs to a class of drugs that can cause the body to retain fluid. This may make blood pressure medications like terazosin less effective.
Terazosin's labeled portfolio outnumbers Ibuprofen
SPL source-record counts only. This page's band is minor · classes on file: Terazosin (Alpha-1 Blocker); Ibuprofen (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 0 moderate · 15 minor · 15 total
- Other minor peers for Terazosin
- Hydrochlorothiazide
- Allopurinol
- Aspirin
- Atenolol
0 major · 2 moderate · 7 minor · 9 total
- Other minor peers for Ibuprofen
- Carbamazepine
- Digoxin
- Fluconazole
- Prenatal Multivitamin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.