Terazosin and Ibuprofen Interaction
Drug interaction information between Terazosin and Ibuprofen.
Terazosin and Ibuprofen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Terazosin and Ibuprofen. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Ibuprofen belongs to a class of drugs that can cause the body to retain fluid. This may make blood pressure medications like terazosin less effective.
What To Do
Let your doctor know if you take ibuprofen regularly. They may want to check your blood pressure to ensure the medicine is still working well.
FDA Label Information
Terazosin has been used concomitantly in at least 50 patients on the following drugs or drug classes: analgesic/anti-inflammatory (e.g., acetaminophen, aspirin, codeine, ibuprofen, indomethacin); antibiotics (e.g., erythromycin, trimethoprim and sulfamethoxazole); anticholinergic/sympathomimetics (e.g., phenylephrine hydrochloride, phenylpropanolamine hydrochloride, pseudoephedrine hydrochloride); antigout (e.g., allopurinol); antihistamines (e.g., chlorpheniramine); cardiovascular agents (e.g., atenolol, hydrochlorothiazide, methyclothiazide, propranolol); corticosteroids;...
Terazosin Also Interacts With
- Hydrochlorothiazide minor
- Allopurinol minor
- Aspirin minor
- Atenolol minor
- Acetaminophen minor
Ibuprofen Also Interacts With
- Heparin moderate
- Warfarin moderate
- Carbamazepine minor
- Digoxin minor
- Fluconazole minor
Frequently Asked Questions
Can I take Terazosin and Ibuprofen together?
This is a minor interaction. Let your doctor know if you take ibuprofen regularly. They may want to check your blood pressure to ensure the medicine is still working well.
How serious is the interaction between Terazosin and Ibuprofen?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Terazosin and Ibuprofen interact?
Ibuprofen belongs to a class of drugs that can cause the body to retain fluid. This may make blood pressure medications like terazosin less effective.
Understanding the Terazosin and Ibuprofen Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Terazosin belongs to the Alpha-1 Blocker class and Ibuprofen belongs to the Nonsteroidal Anti-Inflammatory Drug (NSAID) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Ibuprofen belongs to a class of drugs that can cause the body to retain fluid. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Terazosin has 15 total documented interactions on file in this dataset, and Ibuprofen has 9. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Let your doctor know if you take ibuprofen regularly. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Terazosin or Ibuprofen based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.