Terazosin and Acetaminophen Interaction
Drug interaction information between Terazosin and Acetaminophen.
Terazosin and Acetaminophen have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Terazosin and Acetaminophen. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
These drugs have been used together in many patients without any reported safety issues. They do not typically interfere with how the other drug works in the body.
What To Do
You can take these medicines together as prescribed. No special dosage changes are usually needed.
FDA Label Information
Terazosin has been used concomitantly in at least 50 patients on the following drugs or drug classes: analgesic/anti-inflammatory (e.g., acetaminophen, aspirin, codeine, ibuprofen, indomethacin); antibiotics (e.g., erythromycin, trimethoprim and sulfamethoxazole); anticholinergic/sympathomimetics (e.g., phenylephrine hydrochloride, phenylpropanolamine hydrochloride, pseudoephedrine hydrochloride); antigout (e.g., allopurinol); antihistamines (e.g., chlorpheniramine); cardiovascular agents (e.g., atenolol, hydrochlorothiazide, methyclothiazide, propranolol); corticosteroids;...
Terazosin Also Interacts With
- Hydrochlorothiazide minor
- Ibuprofen minor
- Allopurinol minor
- Aspirin minor
- Atenolol minor
Acetaminophen Also Interacts With
- Dapsone Topical moderate
- Lidocaine Topical moderate
- Acetaminophen/Oxycodone minor
- Carbamazepine minor
- Cidofovir minor
Frequently Asked Questions
Can I take Terazosin and Acetaminophen together?
This is a minor interaction. You can take these medicines together as prescribed. No special dosage changes are usually needed.
How serious is the interaction between Terazosin and Acetaminophen?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Terazosin and Acetaminophen interact?
These drugs have been used together in many patients without any reported safety issues. They do not typically interfere with how the other drug works in the body.
Understanding the Terazosin and Acetaminophen Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Terazosin belongs to the Alpha-1 Blocker class and Acetaminophen belongs to the Analgesic / Antipyretic class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: These drugs have been used together in many patients without any reported safety issues. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Terazosin has 15 total documented interactions on file in this dataset, and Acetaminophen has 23. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: You can take these medicines together as prescribed. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Terazosin or Acetaminophen based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.