darunavir vs tenofovir disoproxil
Side-by-side comparison of darunavir and tenofovir disoproxil. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
minor Known Drug Interaction
HIV-1 Protease Inhibitors : atazanavir lopinavir/ritonavir atazanavir/ritonavir darunavir/ritonavir ↓ atazanavir ↑ tenofovir When coadministered with tenofovir disoproxil fumarate tablets, atazanavir 300 mg should be given with ritonavir 100 mg. Monitor patients receiving tenofovir disoproxil fumarate tablets concomitantly with lopinavir/ritonavir, ritonavir-boosted atazanavir, or ritonavir-boosted darunavir for tenofovir DF-associated adverse reactions.
Recommendation: Your doctor should watch you closely for any side effects while you are taking these two medicines together.
Prezista
Viread
Darunavir is a medicine used to treat HIV. It belongs to a class of drugs called protease inhibitors and must be taken with ritonavir.
Tenofovir disoproxil fumarate is a medicine used to treat HIV and hepatitis B. It helps to lower the amount of virus in your body.
Darunavir is used to treat HIV-1 infection in adults and children 3 years and older. It must be taken with ritonavir and other HIV medicines. Darunavir helps to lower the amount of HIV in your body.
This medicine treats HIV-1 in adults and children at least 2 years old. It is always used with other HIV medicines. It also treats chronic hepatitis B in adults and children at least 12 years old.
Darunavir is a protease inhibitor. It works by blocking an enzyme called protease that HIV needs to make copies of itself. This helps to slow down the spread of HIV in your body.
Tenofovir disoproxil fumarate blocks an enzyme that HIV and hepatitis B need to multiply. This lowers the amount of virus in your body. It can help your immune system get stronger.
- • Diarrhea
- • Nausea
- • Rash
- • Headache
- • Abdominal pain
- • Rash
- • Diarrhea
- • Headache
- • Pain
- • Depression
- Baby exposed to drug during pregnancy 1,150
- Interaction between medicines 981
- Pain 889
- Emotional upset 812
- Worry 811
- Bone Density Decreased 10,625
- Renal Injury 9,276
- Skeletal Injury 8,327
- Chronic Kidney Disease 7,247
- Osteonecrosis 7,245
Darunavir can cause liver problems. Your doctor should check your liver before you start taking darunavir and during treatment. Tell your doctor right away if you have any signs of liver problems, such as yellowing of the skin or eyes.
After stopping this medicine, hepatitis B may get worse. Your doctor will monitor your liver closely for several months after you stop taking it. If needed, you may have to restart hepatitis B treatment.
Tell your doctor if you are pregnant or plan to become pregnant. The recommended dose during pregnancy is 600 mg twice daily with ritonavir 100mg and food. Women with HIV should not breastfeed because HIV can be passed to the baby through breast milk.
Tell your doctor if you are pregnant or plan to become pregnant. HIV-infected mothers should not breastfeed because of the risk of passing HIV to the baby.
How to Read This darunavir vs tenofovir disoproxil Comparison
darunavir is classified in the HIV Protease Inhibitor drug class, while tenofovir disoproxil sits within the Nucleotide Reverse Transcriptase Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, darunavir has 4,643 submissions while tenofovir disoproxil has 42,720. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known minor interaction flagged in FDA labeling, attributed to darunavir can cause the levels of tenofovir in your blood to go up, which makes side effects from tenofovir more likely.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between darunavir and tenofovir disoproxil - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.