What the FDA labels say about taking them together
Abatacept and etanercept
Etanercept's FDA label of May 11, 2026 names abatacept in its drug interactions section; the abatacept label PlainMeds reads does not name etanercept. The etanercept label: “Recommended for Use with Anakinra or Abatacept Use of Enbrel with anakinra or abatacept is not recommended.”
Check it at the source: the abatacept FDA label on DailyMed (effective November 13, 2025, E.R. Squibb & Sons, L.L.C.); the etanercept FDA label on DailyMed (effective May 11, 2026, Immunex Corporation).
What does the abatacept label say about etanercept?
Abatacept's label (effective November 13, 2025) does not name etanercept in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (ORENCIA), E.R. Squibb & Sons, L.L.C., effective November 13, 2025 (SPL set 0836c6ac-ee37-5640-2fed-a3185a0b16eb), via openFDA; the full label on DailyMed
What does the etanercept label say about abatacept?
Etanercept label, drug interactionsLive vaccines – Avoid concurrent administration with Enbrel ( 5.8 , 7.1 ) Anakinra – Increased risk of serious infection ( 5.12 , 7.2 ) Abatacept – Increased risk of serious adverse events, including infections ( 5.12 , 7.2 ) Cyclophosphamide – Not recommended for use with Enbrel.
Etanercept label, warnings and precautionsRecommended for Use with Anakinra or Abatacept Use of Enbrel with anakinra or abatacept is not recommended [see Drug Interactions (7.2) ].
Source: FDA drug label (ENBREL), Immunex Corporation, effective May 11, 2026 (SPL set a002b40c-097d-47a5-957f-7a7b1807af7f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Abatacept | Etanercept | |
|---|---|---|
| Labeled for | Rheumatoid arthritis | Rheumatoid arthritis, Psoriasis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1,469.23 per mL 125 mg/mL syringe | $2,084.14 per mL 25 mg/0.5 mL syringe |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once