Simvastatin and Bempedoic Acid Interaction
Drug interaction information between Simvastatin and Bempedoic Acid.
Simvastatin and Bempedoic Acid have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Simvastatin and Bempedoic Acid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medication increases the amount of simvastatin in your blood. Higher levels of simvastatin can increase your risk of muscle pain or damage.
FDA Label Information
Clinically Important Drug Interactions with NEXLIZET Simvastatin Clinical Impact: Concomitant use of NEXLIZET with simvastatin causes an increase in simvastatin concentration and may increase the risk of simvastatin-related myopathy [see Clinical Pharmacology (12.3) ] . Intervention: Avoid concomitant use of NEXLIZET with simvastatin greater than 20 mg. Simvastatin: Avoid concomitant use of NEXLIZET with simvastatin greater than 20 mg.
Simvastatin Also Interacts With
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
- Dronedarone major
Bempedoic Acid Also Interacts With
- Pravastatin moderate
- Fenofibrate moderate
- Bempedoic Acid/Ezetimibe moderate
- Ezetimibe minor
- Cyclosporine minor
Frequently Asked Questions
What SPL severity band is on file for Simvastatin + Bempedoic Acid?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Simvastatin has 41 labeled pairs on file vs Bempedoic Acid's 7. In the moderate band specifically: Simvastatin has 9 (also Ezetimibe, Daptomycin, Colchicine, Niacin); Bempedoic Acid has 4 (also Pravastatin, Fenofibrate, Bempedoic Acid/Ezetimibe).
What mechanism field is on file for Simvastatin and Bempedoic Acid?
This medication increases the amount of simvastatin in your blood. Higher levels of simvastatin can increase your risk of muscle pain or damage.
Simvastatin carries more major-labeled pairs than Bempedoic Acid
SPL source-record counts only. This page's band is moderate · classes on file: Simvastatin (HMG-CoA Reductase Inhibitor (Statin)); Bempedoic Acid (ACL Inhibitor).
Simvastatin has 11 major-labeled pairs vs Bempedoic Acid's 0. This page itself is in the moderate band, not the major band.
11 major · 9 moderate · 21 minor · 41 total
- Other moderate peers for Simvastatin
- Ezetimibe
- Daptomycin
- Colchicine
- Niacin
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Bempedoic Acid
- Pravastatin
- Fenofibrate
- Bempedoic Acid/Ezetimibe
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.