Bempedoic Acid and Ezetimibe Interaction
Drug interaction information between Bempedoic Acid and Ezetimibe.
Bempedoic Acid and Ezetimibe have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Bempedoic Acid and Ezetimibe. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these medications together can cause the levels of both drugs to increase in your bloodstream.
Bempedoic Acid Also Interacts With
- Simvastatin moderate
- Pravastatin moderate
- Fenofibrate moderate
- Bempedoic Acid/Ezetimibe moderate
- Cyclosporine minor
Ezetimibe Also Interacts With
- Amlodipine major
- Diltiazem major
- Verapamil major
- Cyclosporine major
- Amiodarone major
Frequently Asked Questions
What SPL severity band is on file for Bempedoic Acid + Ezetimibe?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ezetimibe has 25 labeled pairs on file vs Bempedoic Acid's 7. In the minor band specifically: Bempedoic Acid has 3 (also Cyclosporine, Cholestyramine); Ezetimibe has 13 (also Fenofibrate, Ketoconazole, Erythromycin, Clarithromycin).
What mechanism field is on file for Bempedoic Acid and Ezetimibe?
Taking these medications together can cause the levels of both drugs to increase in your bloodstream.
Ezetimibe carries more major-labeled pairs than Bempedoic Acid
SPL source-record counts only. This page's band is minor · classes on file: Bempedoic Acid (ACL Inhibitor); Ezetimibe (Cholesterol Absorption Inhibitor).
Ezetimibe has 8 major-labeled pairs vs Bempedoic Acid's 0. This page itself is in the minor band, not the major band.
0 major · 4 moderate · 3 minor · 7 total
- Other minor peers for Bempedoic Acid
- Cyclosporine
- Cholestyramine
8 major · 4 moderate · 13 minor · 25 total
- Other minor peers for Ezetimibe
- Fenofibrate
- Ketoconazole
- Erythromycin
- Clarithromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.