Bempedoic Acid and Pravastatin Interaction
Drug interaction information between Bempedoic Acid and Pravastatin.
Bempedoic Acid and Pravastatin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Bempedoic Acid and Pravastatin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This drug causes pravastatin levels to rise in your body. This increase can make you more likely to experience muscle-related side effects.
FDA Label Information
Pravastatin Clinical Impact: Concomitant use of NEXLIZET with pravastatin causes an increase in pravastatin concentration and may increase the risk of pravastatin-related myopathy [see Clinical Pharmacology (12.3) ] . Intervention: Avoid concomitant use of NEXLIZET with pravastatin greater than 40 mg. ( 7 ) Pravastatin: Avoid concomitant use of NEXLIZET with pravastatin greater than 40 mg.
Bempedoic Acid Also Interacts With
- Simvastatin moderate
- Fenofibrate moderate
- Bempedoic Acid/Ezetimibe moderate
- Ezetimibe minor
- Cyclosporine minor
Pravastatin Also Interacts With
- Cyclosporine moderate
- Erythromycin moderate
- Clarithromycin moderate
- Colchicine moderate
- Gemfibrozil moderate
Frequently Asked Questions
What SPL severity band is on file for Bempedoic Acid + Pravastatin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Pravastatin has 16 labeled pairs on file vs Bempedoic Acid's 7. In the moderate band specifically: Bempedoic Acid has 4 (also Simvastatin, Fenofibrate, Bempedoic Acid/Ezetimibe); Pravastatin has 9 (also Cyclosporine, Erythromycin, Clarithromycin, Colchicine).
What mechanism field is on file for Bempedoic Acid and Pravastatin?
This drug causes pravastatin levels to rise in your body. This increase can make you more likely to experience muscle-related side effects.
Pravastatin's labeled portfolio outnumbers Bempedoic Acid
SPL source-record counts only. This page's band is moderate · classes on file: Bempedoic Acid (ACL Inhibitor); Pravastatin (HMG-CoA Reductase Inhibitor (Statin)).
0 major · 4 moderate · 3 minor · 7 total
- Other moderate peers for Bempedoic Acid
- Simvastatin
- Fenofibrate
- Bempedoic Acid/Ezetimibe
0 major · 9 moderate · 7 minor · 16 total
- Other moderate peers for Pravastatin
- Cyclosporine
- Erythromycin
- Clarithromycin
- Colchicine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.