Saxagliptin and Lithium Interaction
Drug interaction information between Saxagliptin and Lithium.
Saxagliptin and Lithium have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Saxagliptin and Lithium. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medication can cause your body to get rid of lithium more quickly, leading to lower levels in your blood.
FDA Label Information
Lithium Clinical Impact Concomitant use of an SGLT2 inhibitor with lithium may decrease serum lithium concentrations. Intervention Monitor serum lithium concentration more frequently during QTERN initiation and dosage changes.
Saxagliptin Also Interacts With
- Ketoconazole major
- Clarithromycin minor
- Itraconazole minor
- Nirmatrelvir/Ritonavir minor
Lithium Also Interacts With
- Amlodipine/Benazepril major
- Risperidone major
- Amiloride moderate
- Amiodarone moderate
- Amlodipine/Valsartan moderate
Frequently Asked Questions
What SPL severity band is on file for Saxagliptin + Lithium?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Lithium has 90 labeled pairs on file vs Saxagliptin's 5. In the minor band specifically: Saxagliptin has 4 (also Clarithromycin, Itraconazole, Nirmatrelvir/Ritonavir); Lithium has 65 (also Aripiprazole, Asenapine, Canagliflozin, Candesartan).
What mechanism field is on file for Saxagliptin and Lithium?
This medication can cause your body to get rid of lithium more quickly, leading to lower levels in your blood.
Lithium carries more major-labeled pairs than Saxagliptin
SPL source-record counts only. This page's band is minor · classes on file: Saxagliptin (DPP-4 Inhibitor); Lithium (Mood Stabilizer).
Lithium has 2 major-labeled pairs vs Saxagliptin's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 4 minor · 5 total
- Other minor peers for Saxagliptin
- Clarithromycin
- Itraconazole
- Nirmatrelvir/Ritonavir
2 major · 23 moderate · 65 minor · 90 total
- Other minor peers for Lithium
- Aripiprazole
- Asenapine
- Canagliflozin
- Candesartan
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.