Saxagliptin and Clarithromycin Interaction
Drug interaction information between Saxagliptin and Clarithromycin.
Saxagliptin and Clarithromycin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Saxagliptin and Clarithromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Clarithromycin stops the body from breaking down saxagliptin, which can lead to higher levels of the drug in your system.
FDA Label Information
Similar significant increases in plasma concentrations of saxagliptin are anticipated with other strong CYP3A4/5 inhibitors (e.g., atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, ritonavir, saquinavir, and telithromycin).
Saxagliptin Also Interacts With
- Ketoconazole major
- Lithium minor
- Itraconazole minor
- Nirmatrelvir/Ritonavir minor
Clarithromycin Also Interacts With
- Quetiapine major
- Pioglitazone major
- Fluconazole major
- Cyclosporine major
- Lurasidone major
Frequently Asked Questions
What SPL severity band is on file for Saxagliptin + Clarithromycin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Clarithromycin has 81 labeled pairs on file vs Saxagliptin's 5. In the minor band specifically: Saxagliptin has 4 (also Lithium, Itraconazole, Nirmatrelvir/Ritonavir); Clarithromycin has 30 (also Amlodipine, Lorazepam, Diltiazem, Erythromycin).
What mechanism field is on file for Saxagliptin and Clarithromycin?
Clarithromycin stops the body from breaking down saxagliptin, which can lead to higher levels of the drug in your system.
Clarithromycin carries more major-labeled pairs than Saxagliptin
SPL source-record counts only. This page's band is minor · classes on file: Saxagliptin (DPP-4 Inhibitor); Clarithromycin (Macrolide Antibiotic).
Clarithromycin has 16 major-labeled pairs vs Saxagliptin's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 4 minor · 5 total
- Other minor peers for Saxagliptin
- Lithium
- Itraconazole
- Nirmatrelvir/Ritonavir
16 major · 35 moderate · 30 minor · 81 total
- Other minor peers for Clarithromycin
- Amlodipine
- Lorazepam
- Diltiazem
- Erythromycin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.