Saxagliptin and Ketoconazole Interaction
Drug interaction information between Saxagliptin and Ketoconazole.
Saxagliptin and Ketoconazole have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Saxagliptin and Ketoconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ketoconazole blocks the enzymes that clear saxagliptin from your body, which significantly increases the amount of drug in your blood.
FDA Label Information
7 DRUG INTERACTIONS Table 3: Clinically Relevant Interactions with QTERN Strong Inhibitors of CYP3A4/5 Enzymes Clinical Impact Ketoconazole significantly increased saxagliptin exposure. • Strong CYP3A4/5 Inhibitors (e.g., Ketoconazole): Do not coadminister QTERN with strong cytochrome P450 3A4/5 inhibitors.
Saxagliptin Also Interacts With
- Lithium minor
- Clarithromycin minor
- Itraconazole minor
- Nirmatrelvir/Ritonavir minor
Ketoconazole Also Interacts With
- Alfuzosin major
- Dronedarone major
- Ranolazine major
- Sildenafil major
- Theophylline major
Frequently Asked Questions
What SPL severity band is on file for Saxagliptin + Ketoconazole?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ketoconazole has 113 labeled pairs on file vs Saxagliptin's 5. In the major band specifically: Saxagliptin has 1; Ketoconazole has 6 (also Alfuzosin, Dronedarone, Ranolazine, Sildenafil).
What mechanism field is on file for Saxagliptin and Ketoconazole?
Ketoconazole blocks the enzymes that clear saxagliptin from your body, which significantly increases the amount of drug in your blood.
Ketoconazole carries more major-labeled pairs than Saxagliptin
SPL source-record counts only. This page's band is major · classes on file: Saxagliptin (DPP-4 Inhibitor); Ketoconazole (Azole Antifungal).
Ketoconazole has 6 major-labeled pairs vs Saxagliptin's 1.
1 major · 0 moderate · 4 minor · 5 total
Saxagliptin has no other major-band peer in this dataset besides Ketoconazole.
6 major · 22 moderate · 85 minor · 113 total
- Other major peers for Ketoconazole
- Alfuzosin
- Dronedarone
- Ranolazine
- Sildenafil
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.