Saxagliptin and Nirmatrelvir/Ritonavir Interaction
Drug interaction information between Saxagliptin and Nirmatrelvir/Ritonavir.
Saxagliptin and Nirmatrelvir/Ritonavir have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Saxagliptin and Nirmatrelvir/Ritonavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Ritonavir slows down the body's ability to clear saxagliptin, which causes the drug levels to rise.
FDA Label Information
Dipeptidyl peptidase 4 (DPP4) inhibitors saxagliptin ↑ saxagliptin Dosage adjustment of saxagliptin is recommended. Refer to the saxagliptin product label for more information.
Saxagliptin Also Interacts With
- Ketoconazole major
- Lithium minor
- Clarithromycin minor
- Itraconazole minor
Nirmatrelvir/Ritonavir Also Interacts With
- Simvastatin major
- Lovastatin major
- Sildenafil major
- Carbamazepine major
- Rifampin major
Frequently Asked Questions
What SPL severity band is on file for Saxagliptin + Nirmatrelvir/Ritonavir?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Nirmatrelvir/Ritonavir has 86 labeled pairs on file vs Saxagliptin's 5. In the minor band specifically: Saxagliptin has 4 (also Lithium, Clarithromycin, Itraconazole); Nirmatrelvir/Ritonavir has 33 (also Atorvastatin, Bupropion, Trazodone, Prednisone).
What mechanism field is on file for Saxagliptin and Nirmatrelvir/Ritonavir?
Ritonavir slows down the body's ability to clear saxagliptin, which causes the drug levels to rise.
Nirmatrelvir/Ritonavir carries more major-labeled pairs than Saxagliptin
SPL source-record counts only. This page's band is minor · classes on file: Saxagliptin (DPP-4 Inhibitor); Nirmatrelvir/Ritonavir (Antiviral (Protease Inhibitor Combination)).
Nirmatrelvir/Ritonavir has 23 major-labeled pairs vs Saxagliptin's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 4 minor · 5 total
- Other minor peers for Saxagliptin
- Lithium
- Clarithromycin
- Itraconazole
23 major · 30 moderate · 33 minor · 86 total
- Other minor peers for Nirmatrelvir/Ritonavir
- Atorvastatin
- Bupropion
- Trazodone
- Prednisone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.