Saxagliptin and Itraconazole Interaction
Drug interaction information between Saxagliptin and Itraconazole.
Saxagliptin and Itraconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Saxagliptin and Itraconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Itraconazole blocks the enzymes that process saxagliptin, which can make the diabetes medicine stay in your system longer.
FDA Label Information
Antidiabetic Drugs Repaglinide a Saxagliptin Monitor for adverse reactions.
Saxagliptin Also Interacts With
- Ketoconazole major
- Lithium minor
- Clarithromycin minor
- Nirmatrelvir/Ritonavir minor
Itraconazole Also Interacts With
- Isavuconazonium major
- Lurasidone major
- Pimozide major
- Methadone major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Saxagliptin + Itraconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Itraconazole has 116 labeled pairs on file vs Saxagliptin's 5. In the minor band specifically: Saxagliptin has 4 (also Lithium, Clarithromycin, Nirmatrelvir/Ritonavir); Itraconazole has 77 (also Fluticasone, Meloxicam, Buspirone, Oxycodone).
What mechanism field is on file for Saxagliptin and Itraconazole?
Itraconazole blocks the enzymes that process saxagliptin, which can make the diabetes medicine stay in your system longer.
Itraconazole carries more major-labeled pairs than Saxagliptin
SPL source-record counts only. This page's band is minor · classes on file: Saxagliptin (DPP-4 Inhibitor); Itraconazole (Azole Antifungal).
Itraconazole has 19 major-labeled pairs vs Saxagliptin's 1. This page itself is in the minor band, not the major band.
1 major · 0 moderate · 4 minor · 5 total
- Other minor peers for Saxagliptin
- Lithium
- Clarithromycin
- Nirmatrelvir/Ritonavir
19 major · 20 moderate · 77 minor · 116 total
- Other minor peers for Itraconazole
- Fluticasone
- Meloxicam
- Buspirone
- Oxycodone
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.