Glecaprevir/Pibrentasvir and Estradiol Interaction
Drug interaction information between Glecaprevir/Pibrentasvir and Estradiol.
Glecaprevir/Pibrentasvir and Estradiol have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Glecaprevir/Pibrentasvir and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two drugs at the same time can cause a rise in liver enzymes. This is a sign that the combination might be harmful to your liver.
FDA Label Information
Co-administration of Iclevia and glecaprevir/pibrentasvir is not recommended due to potential for ALT elevations.
Glecaprevir/Pibrentasvir Also Interacts With
- Rifampin major
- Rosuvastatin major
- Rosuvastatin/Ezetimibe major
- Cyclosporine moderate
- Darunavir moderate
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
- Lamotrigine minor
Frequently Asked Questions
What SPL severity band is on file for Glecaprevir/Pibrentasvir + Estradiol?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Glecaprevir/Pibrentasvir's 38. In the moderate band specifically: Glecaprevir/Pibrentasvir has 9 (also Cyclosporine, Darunavir, Ethinyl Estradiol, Ethinyl Estradiol); Estradiol has 3 (also Etonogestrel, Tacrolimus Topical).
What mechanism field is on file for Glecaprevir/Pibrentasvir and Estradiol?
Taking these two drugs at the same time can cause a rise in liver enzymes. This is a sign that the combination might be harmful to your liver.
Glecaprevir/Pibrentasvir carries more major-labeled pairs than Estradiol
SPL source-record counts only. This page's band is moderate · classes on file: Glecaprevir/Pibrentasvir (NS3/4A/NS5A Inhibitor (HCV)); Estradiol (Estrogen Hormone).
Glecaprevir/Pibrentasvir has 3 major-labeled pairs vs Estradiol's 1. This page itself is in the moderate band, not the major band.
3 major · 9 moderate · 26 minor · 38 total
- Other moderate peers for Glecaprevir/Pibrentasvir
- Cyclosporine
- Darunavir
- Ethinyl Estradiol
- Ethinyl Estradiol
1 major · 3 moderate · 50 minor · 54 total
- Other moderate peers for Estradiol
- Etonogestrel
- Tacrolimus Topical
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.