Rivaroxaban and Erythromycin Interaction
Drug interaction information between Rivaroxaban and Erythromycin.
Rivaroxaban and Erythromycin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Rivaroxaban and Erythromycin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Erythromycin slows down how your body breaks down and removes rivaroxaban. This can cause the drug to build up in your system, especially if your kidneys are not working perfectly.
FDA Label Information
Interaction with Combined P-gp and Moderate CYP3A Inhibitors in Patients with Renal Impairment XARELTO should not be used in patients with CrCl 15 to <80 mL/min who are receiving concomitant combined P-gp and moderate CYP3A inhibitors (e.g., erythromycin) unless the potential benefit justifies the potential risk [see Warnings and Precautions (5.4) and Clinical Pharmacology (12.3) ] .
Rivaroxaban Also Interacts With
- Clopidogrel moderate
- Aspirin moderate
- Warfarin moderate
- Ketoconazole moderate
- Carbamazepine moderate
Erythromycin Also Interacts With
- Eplerenone major
- Pitavastatin major
- Risperidone major
- Sildenafil major
- Lefamulin moderate
Frequently Asked Questions
What SPL severity band is on file for Rivaroxaban + Erythromycin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Erythromycin has 63 labeled pairs on file vs Rivaroxaban's 14. In the moderate band specifically: Rivaroxaban has 13 (also Clopidogrel, Aspirin, Warfarin, Ketoconazole); Erythromycin has 6 (also Lefamulin, Lovastatin, Midazolam, Pravastatin).
What mechanism field is on file for Rivaroxaban and Erythromycin?
Erythromycin slows down how your body breaks down and removes rivaroxaban. This can cause the drug to build up in your system, especially if your kidneys are not working perfectly.
Erythromycin carries more major-labeled pairs than Rivaroxaban
SPL source-record counts only. This page's band is moderate · classes on file: Rivaroxaban (Direct Oral Anticoagulant (Factor Xa Inhibitor)); Erythromycin (Macrolide Antibiotic).
Erythromycin has 4 major-labeled pairs vs Rivaroxaban's 0. This page itself is in the moderate band, not the major band.
0 major · 13 moderate · 1 minor · 14 total
- Other moderate peers for Rivaroxaban
- Clopidogrel
- Aspirin
- Warfarin
- Ketoconazole
4 major · 6 moderate · 53 minor · 63 total
- Other moderate peers for Erythromycin
- Lefamulin
- Lovastatin
- Midazolam
- Pravastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.