Glipizide and Colesevelam Interaction
Drug interaction information between Glipizide and Colesevelam.
Glipizide and Colesevelam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glipizide and Colesevelam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Colesevelam can bind to glipizide in your digestive system, which stops the medicine from being absorbed into your body. This makes the glipizide less effective at controlling your blood sugar.
FDA Label Information
In studies assessing the effect of colesevelam on the pharmacokinetics of glipizide ER in healthy volunteers, reductions in glipizide AUC 0-∞ and C max of 12% and 13%, respectively were observed when colesevelam was co-administered with glipizide ER. When glipizide ER was administered 4 hours prior to colesevelam, there was no significant change in glipizide AUC 0-∞ or C max , -4% and 0%, respectively. Therefore, glipizide should be administered at least 4 hours prior to colesevelam to ensure that colesevelam does not reduce the absorption of glipizide.
Glipizide Also Interacts With
- Fluconazole minor
- Probenecid minor
- Phenytoin minor
- Lovastatin minor
- Posaconazole minor
Colesevelam Also Interacts With
- Olmesartan moderate
- Metformin minor
- Warfarin minor
- Norethindrone minor
- Cyclosporine minor
Frequently Asked Questions
What SPL severity band is on file for Glipizide + Colesevelam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Colesevelam has 15 labeled pairs on file vs Glipizide's 8. In the minor band specifically: Glipizide has 8 (also Fluconazole, Probenecid, Phenytoin, Lovastatin); Colesevelam has 14 (also Metformin, Warfarin, Norethindrone, Cyclosporine).
What mechanism field is on file for Glipizide and Colesevelam?
Colesevelam can bind to glipizide in your digestive system, which stops the medicine from being absorbed into your body. This makes the glipizide less effective at controlling your blood sugar.
Colesevelam's labeled portfolio outnumbers Glipizide
SPL source-record counts only. This page's band is minor · classes on file: Glipizide (Sulfonylurea); Colesevelam (Bile Acid Sequestrant (Diabetes)).
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Glipizide
- Fluconazole
- Probenecid
- Phenytoin
- Lovastatin
0 major · 1 moderate · 14 minor · 15 total
- Other minor peers for Colesevelam
- Metformin
- Warfarin
- Norethindrone
- Cyclosporine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.