What the FDA labels say about taking them together
Colesevelam and glipizide
Colesevelam's FDA label of December 28, 2023 names glipizide in its drug interactions section, and glipizide's label names colesevelam too. The colesevelam label: “In vivo drug interactions studies showed a decrease in sulfonylureas when coadministered with colesevelam hydrochloride.”
Check it at the source: the colesevelam FDA label on DailyMed (effective December 28, 2023, A-S Medication Solutions); the glipizide FDA label on DailyMed (effective January 8, 2026, Aurobindo Pharma Limited).
What does the colesevelam label say about glipizide?
Colesevelam label, drug interactionsSulfonylureas Clinical Impact: In vivo drug interactions studies showed a decrease in sulfonylureas when coadministered with colesevelam hydrochloride. Intervention: Administer sulfonylureas 4 hours prior to colesevelam hydrochloride. Examples: Glimepiride, glipizide, and glyburide
Source: FDA drug label (COLESEVELAM HYDROCHLORIDE), NDA021176 (Cosette), as published by A-S Medication Solutions, effective December 28, 2023 (SPL set 0127afae-8d8d-43f2-97f9-4f99f6947e81), via openFDA; the full label on DailyMed
What does the glipizide label say about colesevelam?
Glipizide label, drug interactionsGlipizide extended-release tablets should be administered at least 4 hours prior to colesevelam ( 7.4 , 12.3 ).
Glucotrol Xl label (Roerig, July 21, 2026), drug interactionsAn increase in GLUCOTROL AUC was seen after fluconazole administration ( 7.3 , 12.3 ). ▪ Colesevelam:
Source: FDA drug label (Glucotrol Xl, NDA020329), Roerig, effective July 21, 2026 (SPL set eed99b60-d043-4249-9b2a-f05e46fb588d), via openFDA
Source: FDA drug label (Glipizide), Aurobindo Pharma Limited, effective January 8, 2026 (SPL set 84794a52-b717-488c-8533-6425c83d405f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Colesevelam | Glipizide | |
|---|---|---|
| Labeled for | High cholesterol, Type 2 diabetes | Type 2 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.262 per tablet 625 mg tablet | $0.0339 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once