Glipizide and Phenytoin Interaction
Drug interaction information between Glipizide and Phenytoin.
Glipizide and Phenytoin have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glipizide and Phenytoin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Phenytoin can interfere with how glipizide controls blood sugar, potentially causing your blood sugar levels to rise.
FDA Label Information
These drugs include the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid.
Glipizide Also Interacts With
- Fluconazole minor
- Colesevelam minor
- Probenecid minor
- Lovastatin minor
- Posaconazole minor
Phenytoin Also Interacts With
- Nirmatrelvir/Ritonavir major
- Posaconazole major
- Ranolazine major
- Voriconazole major
- Apixaban moderate
Frequently Asked Questions
What SPL severity band is on file for Glipizide + Phenytoin?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Phenytoin has 147 labeled pairs on file vs Glipizide's 8. In the minor band specifically: Glipizide has 8 (also Fluconazole, Colesevelam, Probenecid, Lovastatin); Phenytoin has 120 (also Atorvastatin, Omeprazole, Simvastatin, Methylphenidate).
What mechanism field is on file for Glipizide and Phenytoin?
Phenytoin can interfere with how glipizide controls blood sugar, potentially causing your blood sugar levels to rise.
Phenytoin carries more major-labeled pairs than Glipizide
SPL source-record counts only. This page's band is minor · classes on file: Glipizide (Sulfonylurea); Phenytoin (Anticonvulsant (Hydantoin)).
Phenytoin has 4 major-labeled pairs vs Glipizide's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Glipizide
- Fluconazole
- Colesevelam
- Probenecid
- Lovastatin
4 major · 23 moderate · 120 minor · 147 total
- Other minor peers for Phenytoin
- Atorvastatin
- Omeprazole
- Simvastatin
- Methylphenidate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.