Glipizide and Fluconazole Interaction
Drug interaction information between Glipizide and Fluconazole.
Glipizide and Fluconazole have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glipizide and Fluconazole. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Fluconazole slows down the way your body breaks down glipizide, which causes the medicine to build up in your blood. This can lead to a dangerous drop in blood sugar levels.
FDA Label Information
The effect of concomitant administration of DIFLUCAN ® (fluconazole) and glipizide has been demonstrated in a placebo-controlled crossover study in normal volunteers. All subjects received glipizide alone and following treatment with 100 mg of DIFLUCAN as a single daily oral dose for 7 days. The mean percentage increase in the glipizide AUC after fluconazole administration was 56.9% (range: 35 to 81).
Glipizide Also Interacts With
- Colesevelam minor
- Probenecid minor
- Phenytoin minor
- Lovastatin minor
- Posaconazole minor
Fluconazole Also Interacts With
- Pimozide major
- Clarithromycin major
- Eplerenone major
- Atorvastatin moderate
- Simvastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Glipizide + Fluconazole?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Fluconazole has 67 labeled pairs on file vs Glipizide's 8. In the minor band specifically: Glipizide has 8 (also Colesevelam, Probenecid, Phenytoin, Lovastatin); Fluconazole has 57 (also Amlodipine, Losartan, Hydrochlorothiazide, Meloxicam).
What mechanism field is on file for Glipizide and Fluconazole?
Fluconazole slows down the way your body breaks down glipizide, which causes the medicine to build up in your blood. This can lead to a dangerous drop in blood sugar levels.
Fluconazole carries more major-labeled pairs than Glipizide
SPL source-record counts only. This page's band is minor · classes on file: Glipizide (Sulfonylurea); Fluconazole (Azole Antifungal).
Fluconazole has 3 major-labeled pairs vs Glipizide's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Glipizide
- Colesevelam
- Probenecid
- Phenytoin
- Lovastatin
3 major · 7 moderate · 57 minor · 67 total
- Other minor peers for Fluconazole
- Amlodipine
- Losartan
- Hydrochlorothiazide
- Meloxicam
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.