What the FDA labels say about taking them together
Fluconazole and glipizide
Fluconazole's FDA label (Fluconazole) of April 2, 2026 names glipizide in its drug interactions section, and glipizide's label names fluconazole too. The glipizide label: “An increase in glipizide AUC was seen after fluconazole administration.”
Check it at the source: the fluconazole FDA label on DailyMed (effective April 7, 2026, Zydus Pharmaceuticals (USA) Inc.); the glipizide FDA label on DailyMed (effective January 8, 2026, Aurobindo Pharma Limited).
What does the fluconazole label say about glipizide?
Fluconazole label (Mylan Pharmaceuticals Inc., April 2, 2026), drug interactionsFluconazole reduces the metabolism of tolbutamide, glyburide, and glipizide and increases the plasma concentration of these agents.
Source: FDA drug label (Fluconazole, NDA020090), Mylan Pharmaceuticals Inc., effective April 2, 2026 (SPL set 737e0fac-a2d2-4053-a0d7-edbfb6248f69), via openFDA
Source: FDA drug label (fluconazole), Zydus Pharmaceuticals (USA) Inc., effective April 7, 2026 (SPL set d1364455-1537-46d4-b093-38cca3be778f), via openFDA; the full label on DailyMed
What does the glipizide label say about fluconazole?
Glipizide label, drug interactionsAn increase in glipizide AUC was seen after fluconazole administration ( 7.3 , 12.3 ).
Glucotrol Xl label (Roerig, July 21, 2026), drug interactionsSevere hypoglycemia can occur when GLUCOTROL and oral miconazole are used concomitantly ( 7.2 , 12.3 ). ▪ Fluconazole: Monitor patients closely.
Source: FDA drug label (Glucotrol Xl, NDA020329), Roerig, effective July 21, 2026 (SPL set eed99b60-d043-4249-9b2a-f05e46fb588d), via openFDA
Source: FDA drug label (Glipizide), Aurobindo Pharma Limited, effective January 8, 2026 (SPL set 84794a52-b717-488c-8533-6425c83d405f), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Fluconazole | Glipizide | |
|---|---|---|
| Labeled for | Fungal infections, Urinary tract infections | Type 2 diabetes |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.380 per tablet 200 mg tablet | $0.0339 per tablet 5 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once