Glipizide and Probenecid Interaction
Drug interaction information between Glipizide and Probenecid.
Glipizide and Probenecid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glipizide and Probenecid. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Probenecid can strengthen the effect of glipizide, which may cause your blood sugar to drop too low. It does this by slowing down how the body removes the medicine or by changing how it travels in the blood.
What To Do
Watch for signs of low blood sugar and check your levels frequently. Your doctor may need to adjust your medication plan.
FDA Label Information
Drug Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including non-steroidal anti-inflammatory agents, some azoles, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, quinolones and beta-adrenergic blocking agents.
Glipizide Also Interacts With
- Fluconazole minor
- Colesevelam minor
- Phenytoin minor
- Lovastatin minor
- Posaconazole minor
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
Can I take Glipizide and Probenecid together?
This is a minor interaction. Watch for signs of low blood sugar and check your levels frequently. Your doctor may need to adjust your medication plan.
How serious is the interaction between Glipizide and Probenecid?
This interaction is classified as "minor" severity by the FDA. Minor interactions are unlikely to cause significant problems but should still be mentioned to your healthcare provider.
Why do Glipizide and Probenecid interact?
Probenecid can strengthen the effect of glipizide, which may cause your blood sugar to drop too low. It does this by slowing down how the body removes the medicine or by changing how it travels in the blood.
Understanding the Glipizide and Probenecid Interaction
FDA-approved prescribing information for these two drugs flags their combination as a minor-severity interaction. Glipizide belongs to the Sulfonylurea class and Probenecid belongs to the Uricosuric Agent class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Probenecid can strengthen the effect of glipizide, which may cause your blood sugar to drop too low. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Glipizide has 8 total documented interactions on file in this dataset, and Probenecid has 37. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Watch for signs of low blood sugar and check your levels frequently. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Glipizide or Probenecid based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.