Glipizide and Probenecid Interaction
Drug interaction information between Glipizide and Probenecid.
Glipizide and Probenecid have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Glipizide and Probenecid. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Probenecid can strengthen the effect of glipizide, which may cause your blood sugar to drop too low. It does this by slowing down how the body removes the medicine or by changing how it travels in the blood.
FDA Label Information
Drug Interactions The hypoglycemic action of sulfonylureas may be potentiated by certain drugs including non-steroidal anti-inflammatory agents, some azoles, and other drugs that are highly protein bound, salicylates, sulfonamides, chloramphenicol, probenecid, coumarins, monoamine oxidase inhibitors, quinolones and beta-adrenergic blocking agents.
Glipizide Also Interacts With
- Fluconazole minor
- Colesevelam minor
- Phenytoin minor
- Lovastatin minor
- Posaconazole minor
Probenecid Also Interacts With
- Ketorolac major
- Levofloxacin major
- Amoxicillin moderate
- Amoxicillin/Clavulanate moderate
- Ceftazidime/Avibactam moderate
Frequently Asked Questions
What SPL severity band is on file for Glipizide + Probenecid?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Probenecid has 37 labeled pairs on file vs Glipizide's 8. In the minor band specifically: Glipizide has 8 (also Fluconazole, Colesevelam, Phenytoin, Lovastatin); Probenecid has 23 (also Theophylline, Acetaminophen/Oxycodone, Ampicillin/Sulbactam, Carbidopa/Levodopa).
What mechanism field is on file for Glipizide and Probenecid?
Probenecid can strengthen the effect of glipizide, which may cause your blood sugar to drop too low. It does this by slowing down how the body removes the medicine or by changing how it travels in the blood.
Probenecid carries more major-labeled pairs than Glipizide
SPL source-record counts only. This page's band is minor · classes on file: Glipizide (Sulfonylurea); Probenecid (Uricosuric Agent).
Probenecid has 2 major-labeled pairs vs Glipizide's 0. This page itself is in the minor band, not the major band.
0 major · 0 moderate · 8 minor · 8 total
- Other minor peers for Glipizide
- Fluconazole
- Colesevelam
- Phenytoin
- Lovastatin
2 major · 12 moderate · 23 minor · 37 total
- Other minor peers for Probenecid
- Theophylline
- Acetaminophen/Oxycodone
- Ampicillin/Sulbactam
- Carbidopa/Levodopa
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.