What the FDA labels say about taking them together
Propranolol and rifampin
Propranolol's FDA label of January 15, 2026 names rifampin in its drug interactions section; the rifampin label PlainMeds reads does not name propranolol. The propranolol label: “CYP1A2 inducers (phenytoin, phenobarbital) or CYP2C19 inducers (rifampin) decrease propranolol plasma concentration when co-administered.”
Check it at the source: the propranolol FDA label on DailyMed (effective January 15, 2026, Mylan Pharmaceuticals Inc.); the rifampin FDA label on DailyMed (effective February 11, 2026, Lupin Pharmaceuticals, Inc.).
What does the propranolol label say about rifampin?
Propranolol label, drug interactionsInducers of Hepatic Drug Metabolism Blood levels of propranolol may be decreased by co-administration with inducers such as rifampin, ethanol, phenytoin, and phenobarbital.
Inderal Xl label (ANI Pharmaceuticals, Inc., August 27, 2026), drug interactionsCYP1A2 and CYP2C19 Inducers: CYP1A2 inducers (e.g., phenytoin, montelukast, smoking) and CYP2C19 inducers (e.g. rifampin) decrease the plasma levels of propranolol resulting in a loss of efficacy [see Clinical Pharmacology ( 12.7 )].
Hemangeol label (Pierre Fabre Pharmaceuticals, Inc., June 25, 2026), drug interactionsCYP1A2 inducers (phenytoin, phenobarbital) or CYP2C19 inducers (rifampin) decrease propranolol plasma concentration when co-administered.
Source: FDA drug label (Inderal Xl, NDA021438), ANI Pharmaceuticals, Inc., effective August 27, 2026 (SPL set ac196ff5-9215-402b-bc57-69aa87f8bade), via openFDA
Source: FDA drug label (Hemangeol, NDA205410), Pierre Fabre Pharmaceuticals, Inc., effective June 25, 2026 (SPL set b6f9dd2a-632b-87eb-70f0-b2064d7ed48a), via openFDA
Source: FDA drug label (Propranolol Hydrochloride), Mylan Pharmaceuticals Inc., effective January 15, 2026 (SPL set b94dcec7-7633-4a33-9cea-48161adeaf93), via openFDA; the full label on DailyMed
What does the rifampin label say about propranolol?
Rifampin's label (effective February 11, 2026) does not name propranolol in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (rifampin), Lupin Pharmaceuticals, Inc., effective February 11, 2026 (SPL set b56004f0-f23d-47f6-80c7-39884fccbccc), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Propranolol | Rifampin | |
|---|---|---|
| Labeled for | High blood pressure, Angina, Atrial fibrillation, Migraine | n/a |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.0493 per tablet 20 mg tablet | $0.679 per capsule 300 mg capsule |
| Shortage now | In shortage | In shortage |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once