Rifampin and Propranolol Interaction
Drug interaction information between Rifampin and Propranolol.
Rifampin and Propranolol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Rifampin and Propranolol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Rifampin causes your body to clear propranolol more quickly, which can make the heart medicine less effective.
FDA Label Information
Decrease exposure Beta-blockers Metoprolol Decrease exposure Propranolol Decrease exposure Benzodiazepines Diazepam , Administered with rifampin 1200 mg daily Decrease exposure Benzodiazepine-related drugs Zopiclone Decrease AUC by 82% Zolpidem Decrease AUC by 73% Calcium Channel Blockers Diltiazem Decrease exposure Nifedipine Rifampin 1200 mg administered as a single oral dose 8 hours before administering a single oral dose of nifedipine 10 mg Decrease exposure Verapamil Decrease exposure Corticosteroids Numerous cases in the literature describe a decrease in glucocorticoid effect when...
Rifampin Also Interacts With
- Darunavir major
- Bictegravir/Emtricitabine/Tenofovir major
- Glecaprevir/Pibrentasvir major
- Nirmatrelvir/Ritonavir major
- Pitavastatin major
Frequently Asked Questions
What SPL severity band is on file for Rifampin + Propranolol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Rifampin has 137 labeled pairs on file vs Propranolol's 44. In the minor band specifically: Rifampin has 103 (also Metoprolol, Losartan, Simvastatin, Glipizide); Propranolol has 44 (also Clonidine, Diltiazem, Warfarin, Verapamil).
What mechanism field is on file for Rifampin and Propranolol?
Rifampin causes your body to clear propranolol more quickly, which can make the heart medicine less effective.
Rifampin carries more major-labeled pairs than Propranolol
SPL source-record counts only. This page's band is minor · classes on file: Rifampin (Rifamycin Antibiotic); Propranolol (Non-Selective Beta-Blocker).
Rifampin has 8 major-labeled pairs vs Propranolol's 0. This page itself is in the minor band, not the major band.
8 major · 26 moderate · 103 minor · 137 total
- Other minor peers for Rifampin
- Metoprolol
- Losartan
- Simvastatin
- Glipizide
0 major · 0 moderate · 44 minor · 44 total
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.