Ertugliflozin and Zonisamide Interaction
Drug interaction information between Ertugliflozin and Zonisamide.
Ertugliflozin and Zonisamide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ertugliflozin and Zonisamide. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Both drugs can cause a buildup of acid in the blood. Taking them together increases the risk of a serious condition called lactic acidosis.
What To Do
Your doctor may need to monitor your blood levels more closely. Watch for symptoms like unusual tiredness or trouble breathing.
FDA Label Information
7 DRUG INTERACTIONS Table 3: Clinically Significant Drug Interactions with SEGLUROMET Carbonic Anhydrase Inhibitors Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of Topiramate or other carbonic anhydrase inhibitors (e.g., zonisamide, acetazolamide or dichlorphenamide) with metformin.
Ertugliflozin Also Interacts With
- Metformin moderate
- Topiramate moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
Zonisamide Also Interacts With
- Alogliptin moderate
- Topiramate moderate
- Carbamazepine minor
- Empagliflozin minor
- Empagliflozin/Linagliptin minor
Frequently Asked Questions
Can I take Ertugliflozin and Zonisamide together?
This is a moderate interaction. Your doctor may need to monitor your blood levels more closely. Watch for symptoms like unusual tiredness or trouble breathing.
How serious is the interaction between Ertugliflozin and Zonisamide?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Ertugliflozin and Zonisamide interact?
Both drugs can cause a buildup of acid in the blood. Taking them together increases the risk of a serious condition called lactic acidosis.
Understanding the Ertugliflozin and Zonisamide Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Ertugliflozin belongs to the SGLT2 Inhibitor class and Zonisamide belongs to the Anticonvulsant (Sulfonamide) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Both drugs can cause a buildup of acid in the blood. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Ertugliflozin has 8 total documented interactions on file in this dataset, and Zonisamide has 13. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor may need to monitor your blood levels more closely. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Ertugliflozin or Zonisamide based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.