Prescription medication · SGLT2 Inhibitor
ertugliflozin
Also sold as Steglatro.
Data updated 2026-05-15
- 1,037
- FDA reportsRarely reported
- 8
- InteractionsFew interactions
- $11.43
- Brand price (NADAC)
What the data shows
ertugliflozin (Steglatro) is a prescription SGLT2 Inhibitor, among the least-reported drugs the FDA tracks (1,037 FDA reports), with 8 documented drug interactions.
Reporting volume reflects how widely a drug is used and studied, not how dangerous it is, a FAERS report documents a temporal association, never proof of cause.
Verify with FDA → · CMS NADAC pricing →
Drug Pricing (NADAC)
Brand Price
$11.43/unit
Generic Available
No
MSD SUB MERCK
Pricing data from NADAC (CMS), effective December 18, 2024. Compare all drug costs →
What it does
Information not available.
Common side effects
Diarrhea, Nausea, Vomiting
Key warnings
No specific warnings noted. Always follow your prescriber's instructions.
Side Effects (from patient reports)
Based on 1,037 FDA adverse event reports.
Most-reported reactions
Adverse reactions in FAERS for ertugliflozin, by number of reports
- Feeling sick to your stomach
Feeling sick to your stomach
86 reports
- Urinary tract infection
Urinary tract infection
62 reports
- Throwing up
Throwing up
59 reports
- Fungal infection
Fungal infection
58 reports
- Diabetic ketoacidosis
Diabetic ketoacidosis
51 reports
- High blood sugar
High blood sugar
46 reports
- Feeling lightheaded
Feeling lightheaded
46 reports
- Diarrhea
Diarrhea
43 reports
- Missing a dose of medicine 29
Missing a dose of medicine
29 reports
- Loss of appetite 25
Loss of appetite
25 reports
What this shows Bars show how often each reaction was reported, not how likely it is to happen, a report records a temporal association, never proof that the drug caused it.
Reports over time
Adverse-event reports filed for ertugliflozin each year to the FDA Adverse Event Reporting System (FAERS).
Year-to-year volume tracks usage, prescribing, and scrutiny, not a change in per-patient risk. Source: FDA FAERS.
Where ertugliflozin sits
ertugliflozin has more FDA adverse-event reports than 7% of the drugs FAERS tracks. A high position reflects how widely a drug is used and watched, not how dangerous it is.
Percentile across all drugs PlainMeds tracks by FAERS report volume. The dot is ertugliflozin; the line is the median (50th percentile).
FDA Adverse Event Report Analysis
Detailed analysis of 1,037 reports from the FDA Adverse Event Reporting System (FAERS). Reports span 2013–2025.
Total Reports
1,037
Reports Mentioning Death
12
1.2% of reports — not proof of cause
Hospitalization Reports
290
Top Indication
Type 2 Diabetes Mellitus
Gender Distribution
Age Distribution
Most Reported Adverse Reactions (FAERS)
| # | Reaction | Reports |
|---|---|---|
| 1 | NAUSEA | 86 |
| 3 | URINARY TRACT INFECTION | 62 |
| 4 | VOMITING | 59 |
| 5 | FUNGAL INFECTION | 58 |
| 7 | DIABETIC KETOACIDOSIS | 51 |
| 8 | BLOOD GLUCOSE INCREASED | 46 |
| 9 | DIZZINESS | 46 |
| 10 | DIARRHOEA | 43 |
| 12 | PRODUCT DOSE OMISSION | 29 |
| 13 | DECREASED APPETITE | 25 |
| 14 | DIABETES MELLITUS INADEQUATE CONTROL | 25 |
| 15 | RASH | 25 |
| 16 | FATIGUE | 23 |
| 18 | ASTHENIA | 21 |
| 19 | INABILITY TO AFFORD MEDICATION | 21 |
Reactions in Death Reports
Reactions in Hospitalization Reports
Source: FDA FAERS (Adverse Event Reporting System) FDA FAERS (Adverse Event Reporting System) Reports are voluntary and do not establish causation
Known Drug Interactions
7 DRUG INTERACTIONS Table 3: Clinically Significant Drug Interactions with SEGLUROMET Carbonic Anhydrase Inhibitors Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of Topiramate or other carbonic anhydrase inhibitors (e.g., zonisamide, acetazolamide or dichlorphenamide) with metformin. Drugs that Reduce Metformin Clearance Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2...
Mechanism: Taking these drugs together can increase the risk of a dangerous buildup of lactic acid in the blood, especially if the kidneys are not clearing the medicine properly.
What to do: Your doctor should monitor your kidney function and check for signs of acid buildup in your blood regularly.
7 DRUG INTERACTIONS Table 3: Clinically Significant Drug Interactions with SEGLUROMET Carbonic Anhydrase Inhibitors Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of Topiramate or other carbonic anhydrase inhibitors (e.g., zonisamide, acetazolamide or dichlorphenamide) with metformin.
Mechanism: Topiramate affects how the body handles acid, which can increase the risk of a serious condition called lactic acidosis when combined with metformin.
What to do: Your doctor should monitor you closely for side effects and may need to adjust your medication.
Drugs that Reduce Metformin Clearance Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) which increase systemic exposure to metformin Intervention Consider the benefits and risks of concomitant use.
Mechanism: Dolutegravir blocks the kidneys from removing metformin from the body, which causes metformin levels to rise and increases the risk of side effects.
What to do: Your doctor should carefully consider the risks and benefits of using these two medications at the same time.
Drugs that Reduce Metformin Clearance Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) which increase systemic exposure to metformin Intervention Consider the benefits and risks of concomitant use.
Mechanism: Ranolazine prevents the kidneys from properly filtering metformin out of the blood, which can lead to a higher amount of metformin in your system.
What to do: You and your doctor should discuss the risks of this combination and monitor for any signs of metformin toxicity.
Drugs that Reduce Metformin Clearance Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2 [OCT2] / multidrug and toxin extrusion [MATE] inhibitors such as ranolazine, vandetanib, dolutegravir, and cimetidine) which increase systemic exposure to metformin Intervention Consider the benefits and risks of concomitant use.
Mechanism: Cimetidine interferes with the body's ability to get rid of metformin through the kidneys, which can cause the drug to build up to unsafe levels.
What to do: Your healthcare provider should monitor you closely and decide if the benefits of taking both drugs are worth the risks.
This is a plain-language summary of interactions documented in FDA labeling, not individualized advice. Ask a pharmacist or prescriber before combining medications.
Common Questions
What are the common side effects of ertugliflozin?
Does ertugliflozin interact with other medications?
What drug class is ertugliflozin?
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Medication Guides
Understanding Drug Interactions
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Generic vs Brand Name Drugs
FDA requirements, cost savings, and when the difference matters
Narrow Therapeutic Index Drugs
Why some drugs demand precise dosing and monitoring
Common Drug Interactions
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What the FDA Data Shows for ertugliflozin
The FDA label for ertugliflozin (sold under brand names such as Steglatro) classifies it as a prescription-only medication in the SGLT2 Inhibitor class. Regulatory labeling describes its approved uses and the patient populations studied in pre-market trials. Official labeling lists 9 commonly reported side effects, including Diarrhea, Nausea, Vomiting.
Post-market surveillance from the FDA Adverse Event Reporting System (FAERS) captures real-world experience. For this drug, FAERS contains 1,037 voluntary reports. The database also lists 8 documented drug interactions derived from FDA labeling, with the top-flagged interaction rated moderate severity. NADAC pricing from CMS.
Report counts do not establish causation, a FAERS entry documents a temporal association, not proof that the drug produced the outcome. Widely prescribed medications naturally accumulate more reports than niche therapies, so raw totals must be interpreted alongside total exposure. Shortage status, recall history, and patent information further shape supply and switching decisions. This page summarizes public FDA data for educational purposes only and is not a substitute for professional medical advice, always consult a licensed healthcare provider before starting, stopping, or changing any medication.
Data Sources
Drug labeling: FDA Drug Labels (SPL/DailyMed). Adverse events: FDA Adverse Event Reporting System (FAERS). Pricing: CMS National Average Drug Acquisition Cost (NADAC).
FAERS reports are voluntary and do not establish causation. Drug interactions are derived from FDA labeling and clinical references. Always consult a healthcare professional before making medication decisions.
Last updated: December 20, 2024
Read our methodology - how this data is sourced, computed, and verified.
Data currency: FDA FAERS adverse-event reports through 2025, CMS NADAC acquisition-cost pricing effective December 2024, compiled and last refreshed May 2026. See our methodology for per-source dates and refresh cadence. Spot a figure that looks wrong? Report a correction.
All federal data sources used on this page
- FDA Orange Book - approved drug products with therapeutic equivalence. accessdata.fda.gov/cder/ob
- FDA DailyMed - NIH-hosted drug labeling for FDA-approved meds. dailymed.nlm.nih.gov
- FDA Adverse Event Reporting System (FAERS) - post-marketing safety surveillance. fda.gov/drugs/faers
- NLM RxNorm - standardized clinical drug nomenclature. nlm.nih.gov/research/umls/rxnorm
- CMS Medicare Part B Drug Average Sales Price Files - federal drug pricing data. cms.gov/medicare/part-b-drugs/asp
- FDA Drug Shortages Database - current and resolved drug shortage tracking. accessdata.fda.gov/drugshortages