Ertugliflozin and Topiramate Interaction
Drug interaction information between Ertugliflozin and Topiramate.
Ertugliflozin and Topiramate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ertugliflozin and Topiramate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Topiramate affects how the body handles acid, which can increase the risk of a serious condition called lactic acidosis when combined with metformin.
FDA Label Information
7 DRUG INTERACTIONS Table 3: Clinically Significant Drug Interactions with SEGLUROMET Carbonic Anhydrase Inhibitors Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of Topiramate or other carbonic anhydrase inhibitors (e.g., zonisamide, acetazolamide or dichlorphenamide) with metformin.
Ertugliflozin Also Interacts With
- Metformin moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Zonisamide moderate
Topiramate Also Interacts With
- Zonisamide moderate
- Alogliptin moderate
- Hydrochlorothiazide minor
- Amitriptyline minor
- Pioglitazone minor
Frequently Asked Questions
What SPL severity band is on file for Ertugliflozin + Topiramate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Topiramate has 30 labeled pairs on file vs Ertugliflozin's 8. In the moderate band specifically: Ertugliflozin has 6 (also Metformin, Dolutegravir, Ranolazine, Cimetidine); Topiramate has 3 (also Zonisamide, Alogliptin).
What mechanism field is on file for Ertugliflozin and Topiramate?
Topiramate affects how the body handles acid, which can increase the risk of a serious condition called lactic acidosis when combined with metformin.
Topiramate's labeled portfolio outnumbers Ertugliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Ertugliflozin (SGLT2 Inhibitor); Topiramate (Anticonvulsant).
0 major · 6 moderate · 2 minor · 8 total
- Other moderate peers for Ertugliflozin
- Metformin
- Dolutegravir
- Ranolazine
- Cimetidine
0 major · 3 moderate · 27 minor · 30 total
- Other moderate peers for Topiramate
- Zonisamide
- Alogliptin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.