Ertugliflozin and Metformin Interaction
Drug interaction information between Ertugliflozin and Metformin.
Ertugliflozin and Metformin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ertugliflozin and Metformin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these drugs together can increase the risk of a dangerous buildup of lactic acid in the blood, especially if the kidneys are not clearing the medicine properly.
FDA Label Information
7 DRUG INTERACTIONS Table 3: Clinically Significant Drug Interactions with SEGLUROMET Carbonic Anhydrase Inhibitors Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of Topiramate or other carbonic anhydrase inhibitors (e.g., zonisamide, acetazolamide or dichlorphenamide) with metformin. Drugs that Reduce Metformin Clearance Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2...
Ertugliflozin Also Interacts With
- Topiramate moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Zonisamide moderate
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Linagliptin moderate
Frequently Asked Questions
What SPL severity band is on file for Ertugliflozin + Metformin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Metformin has 27 labeled pairs on file vs Ertugliflozin's 8. In the moderate band specifically: Ertugliflozin has 6 (also Topiramate, Dolutegravir, Ranolazine, Cimetidine); Metformin has 10 (also Bictegravir, Dolutegravir/Lamivudine, Empagliflozin, Empagliflozin/Linagliptin).
What mechanism field is on file for Ertugliflozin and Metformin?
Taking these drugs together can increase the risk of a dangerous buildup of lactic acid in the blood, especially if the kidneys are not clearing the medicine properly.
Metformin's labeled portfolio outnumbers Ertugliflozin
SPL source-record counts only. This page's band is moderate · classes on file: Ertugliflozin (SGLT2 Inhibitor); Metformin (Biguanide).
0 major · 6 moderate · 2 minor · 8 total
- Other moderate peers for Ertugliflozin
- Topiramate
- Dolutegravir
- Ranolazine
- Cimetidine
0 major · 10 moderate · 17 minor · 27 total
- Other moderate peers for Metformin
- Bictegravir
- Dolutegravir/Lamivudine
- Empagliflozin
- Empagliflozin/Linagliptin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.