Ertugliflozin and Metformin Interaction
Drug interaction information between Ertugliflozin and Metformin.
Ertugliflozin and Metformin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Ertugliflozin and Metformin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Taking these drugs together can increase the risk of a dangerous buildup of lactic acid in the blood, especially if the kidneys are not clearing the medicine properly.
What To Do
Your doctor should monitor your kidney function and check for signs of acid buildup in your blood regularly.
FDA Label Information
7 DRUG INTERACTIONS Table 3: Clinically Significant Drug Interactions with SEGLUROMET Carbonic Anhydrase Inhibitors Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of Topiramate or other carbonic anhydrase inhibitors (e.g., zonisamide, acetazolamide or dichlorphenamide) with metformin. Drugs that Reduce Metformin Clearance Clinical Impact: The risk of lactic acidosis may increase due to concomitant use of drugs that interfere with common renal tubular transport systems involved in the renal elimination of metformin (e.g., organic cationic transporter-2...
Ertugliflozin Also Interacts With
- Topiramate moderate
- Dolutegravir moderate
- Ranolazine moderate
- Cimetidine moderate
- Zonisamide moderate
Metformin Also Interacts With
- Bictegravir/Emtricitabine/Tenofovir moderate
- Dolutegravir/Lamivudine moderate
- Empagliflozin moderate
- Empagliflozin/Linagliptin moderate
- Linagliptin moderate
Frequently Asked Questions
Can I take Ertugliflozin and Metformin together?
This is a moderate interaction. Your doctor should monitor your kidney function and check for signs of acid buildup in your blood regularly.
How serious is the interaction between Ertugliflozin and Metformin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Ertugliflozin and Metformin interact?
Taking these drugs together can increase the risk of a dangerous buildup of lactic acid in the blood, especially if the kidneys are not clearing the medicine properly.
Understanding the Ertugliflozin and Metformin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Ertugliflozin belongs to the SGLT2 Inhibitor class and Metformin belongs to the Biguanide class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Taking these drugs together can increase the risk of a dangerous buildup of lactic acid in the blood, especially if the kidneys are not clearing the medicine properly. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Ertugliflozin has 8 total documented interactions on file in this dataset, and Metformin has 27. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Your doctor should monitor your kidney function and check for signs of acid buildup in your blood regularly. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Ertugliflozin or Metformin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.