Prednisolone and Etonogestrel Interaction
Drug interaction information between Prednisolone and Etonogestrel.
Prednisolone and Etonogestrel have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prednisolone and Etonogestrel. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
This medication can prevent your body from clearing prednisolone normally, which might cause the steroid levels in your blood to go up.
FDA Label Information
7.2 Effects of CHCs on Other Drugs CHCs containing ethinyl estradiol may inhibit the metabolism of other compounds (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole) and increase their plasma concentrations.
Prednisolone Also Interacts With
- Theophylline major
- Darunavir moderate
- Nirmatrelvir/Ritonavir moderate
- Carbamazepine minor
- Estradiol minor
Etonogestrel Also Interacts With
- Estradiol moderate
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Amoxicillin minor
- Lamotrigine minor
Frequently Asked Questions
What SPL severity band is on file for Prednisolone + Etonogestrel?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Etonogestrel has 29 labeled pairs on file vs Prednisolone's 14. In the minor band specifically: Prednisolone has 11 (also Carbamazepine, Estradiol, Ethinyl Estradiol, Ethinyl Estradiol); Etonogestrel has 27 (also Atorvastatin, Amoxicillin, Lamotrigine, Topiramate).
What mechanism field is on file for Prednisolone and Etonogestrel?
This medication can prevent your body from clearing prednisolone normally, which might cause the steroid levels in your blood to go up.
Prednisolone carries more major-labeled pairs than Etonogestrel
SPL source-record counts only. This page's band is minor · classes on file: Prednisolone (Corticosteroid); Etonogestrel (Progestin (Implant)).
Prednisolone has 1 major-labeled pair vs Etonogestrel's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 11 minor · 14 total
- Other minor peers for Prednisolone
- Carbamazepine
- Estradiol
- Ethinyl Estradiol
- Ethinyl Estradiol
0 major · 2 moderate · 27 minor · 29 total
- Other minor peers for Etonogestrel
- Atorvastatin
- Amoxicillin
- Lamotrigine
- Topiramate
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.