Prednisolone and Estradiol Interaction
Drug interaction information between Prednisolone and Estradiol.
Prednisolone and Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prednisolone and Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Estradiol can slow down how your body processes prednisolone, which causes the steroid to build up in your system.
FDA Label Information
Concomitant use with ethinyl estradiol-containing COCs may increase systemic exposure of other drugs (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole).
Prednisolone Also Interacts With
- Theophylline major
- Darunavir moderate
- Nirmatrelvir/Ritonavir moderate
- Carbamazepine minor
- Ethinyl Estradiol/Etonogestrel minor
Estradiol Also Interacts With
- Drospirenone/Ethinyl Estradiol major
- Glecaprevir/Pibrentasvir moderate
- Etonogestrel moderate
- Tacrolimus Topical moderate
- Rosuvastatin minor
Frequently Asked Questions
What SPL severity band is on file for Prednisolone + Estradiol?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Estradiol has 54 labeled pairs on file vs Prednisolone's 14. In the minor band specifically: Prednisolone has 11 (also Carbamazepine, Ethinyl Estradiol, Ethinyl Estradiol, Etonogestrel); Estradiol has 50 (also Rosuvastatin, Lamotrigine, Topiramate, Tizanidine).
What mechanism field is on file for Prednisolone and Estradiol?
Estradiol can slow down how your body processes prednisolone, which causes the steroid to build up in your system.
Estradiol's labeled portfolio outnumbers Prednisolone
SPL source-record counts only. This page's band is minor · classes on file: Prednisolone (Corticosteroid); Estradiol (Estrogen Hormone).
1 major · 2 moderate · 11 minor · 14 total
- Other minor peers for Prednisolone
- Carbamazepine
- Ethinyl Estradiol
- Ethinyl Estradiol
- Etonogestrel
1 major · 3 moderate · 50 minor · 54 total
- Other minor peers for Estradiol
- Rosuvastatin
- Lamotrigine
- Topiramate
- Tizanidine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.