Prednisolone and Ethinyl Estradiol Interaction
Drug interaction information between Prednisolone and Ethinyl Estradiol.
Prednisolone and Ethinyl Estradiol have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Prednisolone and Ethinyl Estradiol. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
The birth control ring interferes with how your body processes prednisolone. This can cause the steroid to build up in your blood.
FDA Label Information
7.2 Effects of CHCs on Other Drugs CHCs containing ethinyl estradiol may inhibit the metabolism of other compounds (e.g., cyclosporine, prednisolone, theophylline, tizanidine, and voriconazole) and increase their plasma concentrations.
Prednisolone Also Interacts With
- Theophylline major
- Darunavir moderate
- Nirmatrelvir/Ritonavir moderate
- Carbamazepine minor
- Estradiol minor
Ethinyl Estradiol Also Interacts With
- Glecaprevir/Pibrentasvir moderate
- Atorvastatin minor
- Amoxicillin minor
- Estradiol minor
- Lamotrigine minor
Frequently Asked Questions
What SPL severity band is on file for Prednisolone + Ethinyl Estradiol/Etonogestrel?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Ethinyl Estradiol has 28 labeled pairs on file vs Prednisolone's 14. In the minor band specifically: Prednisolone has 11 (also Carbamazepine, Estradiol, Ethinyl Estradiol, Etonogestrel); Ethinyl Estradiol has 27 (also Atorvastatin, Amoxicillin, Estradiol, Lamotrigine).
What mechanism field is on file for Prednisolone and Ethinyl Estradiol/Etonogestrel?
The birth control ring interferes with how your body processes prednisolone. This can cause the steroid to build up in your blood.
Prednisolone carries more major-labeled pairs than Ethinyl Estradiol
SPL source-record counts only. This page's band is minor · classes on file: Prednisolone (Corticosteroid); Ethinyl Estradiol (Vaginal Contraceptive Ring).
Prednisolone has 1 major-labeled pair vs Ethinyl Estradiol's 0. This page itself is in the minor band, not the major band.
1 major · 2 moderate · 11 minor · 14 total
- Other minor peers for Prednisolone
- Carbamazepine
- Estradiol
- Ethinyl Estradiol
- Etonogestrel
0 major · 1 moderate · 27 minor · 28 total
- Other minor peers for Ethinyl Estradiol
- Atorvastatin
- Amoxicillin
- Estradiol
- Lamotrigine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.