Prednisolone and Darunavir Interaction
Drug interaction information between Prednisolone and Darunavir.
Prednisolone and Darunavir have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Prednisolone and Darunavir. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir has a smaller effect on prednisolone than on other steroids, so the levels do not rise as much. This makes it a safer choice when a steroid is needed.
FDA Label Information
betamethasone budesonide ciclesonide fluticasone methylprednisolone mometasone triamcinolone ↑ corticosteroids Co-administration with corticosteroids (all routes of administration) of which exposures are significantly increased by strong CYP3A inhibitors can increase the risk for Cushing's syndrome and adrenal suppression. Alternative corticosteroids including beclomethasone, prednisone and prednisolone (for which PK and/or PD are less affected by strong CYP3A inhibitors relative to other steroids) should be considered, particularly for long term use.
Prednisolone Also Interacts With
- Theophylline major
- Nirmatrelvir/Ritonavir moderate
- Carbamazepine minor
- Estradiol minor
- Ethinyl Estradiol/Etonogestrel minor
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Frequently Asked Questions
What SPL severity band is on file for Prednisolone + Darunavir?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Prednisolone's 14. In the moderate band specifically: Prednisolone has 2 (also Nirmatrelvir/Ritonavir); Darunavir has 16 (also Omeprazole, Fluticasone, Apixaban, Clopidogrel).
What mechanism field is on file for Prednisolone and Darunavir?
Darunavir has a smaller effect on prednisolone than on other steroids, so the levels do not rise as much. This makes it a safer choice when a steroid is needed.
Darunavir carries more major-labeled pairs than Prednisolone
SPL source-record counts only. This page's band is moderate · classes on file: Prednisolone (Corticosteroid); Darunavir (HIV Protease Inhibitor).
Darunavir has 15 major-labeled pairs vs Prednisolone's 1. This page itself is in the moderate band, not the major band.
1 major · 2 moderate · 11 minor · 14 total
- Other moderate peers for Prednisolone
- Nirmatrelvir/Ritonavir
15 major · 16 moderate · 70 minor · 101 total
- Other moderate peers for Darunavir
- Omeprazole
- Fluticasone
- Apixaban
- Clopidogrel
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.