What the FDA labels say about taking them together
Niacin and pravastatin
Pravastatin's FDA label of July 31, 2026 names niacin in its drug interactions section; niacin's label does not name pravastatin itself but warns about its class (Statins). The pravastatin label: “Cases of myopathy and rhabdomyolysis have been observed with concomitant use of niacin with pravastatin.”
Check it at the source: the niacin FDA label on DailyMed (effective February 14, 2023, Aurobindo Pharma Limited); the pravastatin FDA label on DailyMed (effective July 31, 2026, Apotex Corp.).
What does the niacin label say about pravastatin?
Niacin's label does not name pravastatin itself; it warns about its class (Statins):
Niacin label, drug interactionsCaution should be used when prescribing niacin with statins as these agents can increase risk of myopathy/rhabdomyolysis.
Niacin label, drug interactionsCaution should be used when prescribing niacin (≥1 gm/day) with statins as these drugs can increase risk of myopathy/rhabdomyolysis [see Warnings and Precautions (5) and Clinical Pharmacology (12.3) ].
Source: FDA drug label (Niacin), Aurobindo Pharma Limited, effective February 14, 2023 (SPL set 43233a21-3f90-4c69-bbeb-f50d5f2d35ae), via openFDA; the full label on DailyMed
What does the pravastatin label say about niacin?
Pravastatin label, drug interactionsClinical Impact: Cases of myopathy and rhabdomyolysis have been observed with concomitant use of niacin with pravastatin. Intervention: Consider if the benefit of using niacin concomitantly with pravastatin outweighs the increased risk of myopathy and rhabdomyolysis. If concomitant use is decided, monitor patients for signs and symptoms of myopathy, particularly during initiation of therapy and during upward dose titration of …
Pravastatin label, warnings and precautionsThe following drugs when used concomitantly with pravastatin may also increase the risk of myopathy and rhabdomyolysis: niacin, fibrates, and colchicine [see Drug Interactions ( 7 )].
Source: FDA drug label (PRAVASTATIN SODIUM), Apotex Corp., effective July 31, 2026 (SPL set dcf45e4f-b46e-6fbb-b67a-2ff619ab1780), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Niacin | Pravastatin | |
|---|---|---|
| Labeled for | High cholesterol, Heart attack and coronary artery disease, High triglycerides | Heart attack and coronary artery disease, High cholesterol, High triglycerides |
| Boxed warning | No | No |
| Pharmacy cost (NADAC) | $0.193 per tablet 500 mg tablet | $0.058 per tablet 20 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once