Pitavastatin and Niacin Interaction
Drug interaction information between Pitavastatin and Niacin.
Pitavastatin and Niacin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pitavastatin and Niacin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Using high doses of niacin along with this statin can increase your chances of having severe muscle pain or injury.
FDA Label Information
Niacin Clinical Impact: The risk of myopathy and rhabdomyolysis may be increased with concomitant use of lipid-modifying doses (≥1 g/day) of niacin with pitavastatin tablets. Intervention: Consider if the benefit of using lipid-modifying doses (≥1 g/day) of niacin concomitantly with pitavastatin tablets outweighs the increased risk of myopathy and rhabdomyolysis.
Pitavastatin Also Interacts With
- Cyclosporine major
- Erythromycin major
- Rifampin major
- Colchicine moderate
- Gemfibrozil moderate
Niacin Also Interacts With
- Atorvastatin moderate
- Ezetimibe moderate
- Ezetimibe/Simvastatin moderate
- Fluvastatin moderate
- Lovastatin moderate
Frequently Asked Questions
What SPL severity band is on file for Pitavastatin + Niacin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Niacin has 21 labeled pairs on file vs Pitavastatin's 9. In the moderate band specifically: Pitavastatin has 4 (also Colchicine, Gemfibrozil, Sofosbuvir/Velpatasvir); Niacin has 10 (also Atorvastatin, Ezetimibe, Ezetimibe/Simvastatin, Fluvastatin).
What mechanism field is on file for Pitavastatin and Niacin?
Using high doses of niacin along with this statin can increase your chances of having severe muscle pain or injury.
Pitavastatin carries more major-labeled pairs than Niacin
SPL source-record counts only. This page's band is moderate · classes on file: Pitavastatin (HMG-CoA Reductase Inhibitor (Statin)); Niacin (Vitamin B3 (Lipid-Modifying)).
Pitavastatin has 3 major-labeled pairs vs Niacin's 0. This page itself is in the moderate band, not the major band.
3 major · 4 moderate · 2 minor · 9 total
- Other moderate peers for Pitavastatin
- Colchicine
- Gemfibrozil
- Sofosbuvir/Velpatasvir
0 major · 10 moderate · 11 minor · 21 total
- Other moderate peers for Niacin
- Atorvastatin
- Ezetimibe
- Ezetimibe/Simvastatin
- Fluvastatin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.