Pitavastatin and Niacin Interaction
Drug interaction information between Pitavastatin and Niacin.
Pitavastatin and Niacin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Pitavastatin and Niacin. Major interactions are generally avoided, moderate ones may need monitoring or a dose adjustment, and minor ones are usually low-risk. This page shows the documented mechanism and guidance. Label-documented interactions are not a complete safety review, so always confirm your own medications with a pharmacist or doctor. Educational information, not medical advice.
How They Interact
Using high doses of niacin along with this statin can increase your chances of having severe muscle pain or injury.
What To Do
Talk to your doctor to see if the benefits of this combination outweigh the risks to your muscles.
FDA Label Information
Niacin Clinical Impact: The risk of myopathy and rhabdomyolysis may be increased with concomitant use of lipid-modifying doses (≥1 g/day) of niacin with pitavastatin tablets. Intervention: Consider if the benefit of using lipid-modifying doses (≥1 g/day) of niacin concomitantly with pitavastatin tablets outweighs the increased risk of myopathy and rhabdomyolysis.
Pitavastatin Also Interacts With
- Cyclosporine major
- Erythromycin major
- Rifampin major
- Colchicine moderate
- Gemfibrozil moderate
Niacin Also Interacts With
- Atorvastatin moderate
- Ezetimibe moderate
- Ezetimibe/Simvastatin moderate
- Fluvastatin moderate
- Lovastatin moderate
Frequently Asked Questions
Can I take Pitavastatin and Niacin together?
This is a moderate interaction. Talk to your doctor to see if the benefits of this combination outweigh the risks to your muscles.
How serious is the interaction between Pitavastatin and Niacin?
This interaction is classified as "moderate" severity by the FDA. Moderate interactions may worsen your condition or change how your medications work.
Why do Pitavastatin and Niacin interact?
Using high doses of niacin along with this statin can increase your chances of having severe muscle pain or injury.
Understanding the Pitavastatin and Niacin Interaction
FDA-approved prescribing information for these two drugs flags their combination as a moderate-severity interaction. Pitavastatin belongs to the HMG-CoA Reductase Inhibitor (Statin) class and Niacin belongs to the Vitamin B3 (Lipid-Modifying) class - two categories that can collide when co-prescribed. The mechanism described in FDA labeling is: Using high doses of niacin along with this statin can increase your chances of having severe muscle pain or injury. Severity tiers matter: major flags generally advise avoidance, moderate flags often require monitoring or dose adjustment, and minor flags may only call for awareness.
Context around a specific patient determines real-world impact. Pitavastatin has 9 total documented interactions on file in this dataset, and Niacin has 21. Each additional medication compounds the interaction surface, which is why pharmacists run full-profile checks rather than evaluating one pair at a time. FDA-derived guidance for this pair is: Talk to your doctor to see if the benefits of this combination outweigh the risks to your muscles. Timing of doses, renal and hepatic function, age, and other concurrent prescriptions all shape whether a labeled interaction matters clinically.
An interaction flag is not a verdict. A large share of labeled interactions are managed routinely in clinical practice, the fix may be as simple as spacing doses or adding a monitoring test. Others require the prescriber to choose a different medication entirely. This page surfaces FDA-sourced labeling and openFDA data for educational purposes only; it is not medical advice and cannot account for your full clinical picture. Never start, stop, or adjust either Pitavastatin or Niacin based on a web page, speak with your prescriber or pharmacist before making any change.
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. Always consult your healthcare provider about drug interactions.
Read our methodology - how this data is sourced, computed, and verified.