Piroxicam and Warfarin Interaction
Drug interaction information between Piroxicam and Warfarin.
Piroxicam and Warfarin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Piroxicam and Warfarin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Piroxicam is an anti-inflammatory drug that can increase the risk of bleeding when taken with blood thinners like warfarin. This combination makes it more likely for you to experience serious bleeding issues.
Piroxicam Also Interacts With
- Furosemide moderate
- Methotrexate moderate
- Diflunisal moderate
- Meloxicam minor
- Aspirin minor
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Frequently Asked Questions
What SPL severity band is on file for Piroxicam + Warfarin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Piroxicam's 15. In the moderate band specifically: Piroxicam has 4 (also Furosemide, Methotrexate, Diflunisal); Warfarin has 28 (also Ibuprofen, Aspirin, Diclofenac, Desvenlafaxine).
What mechanism field is on file for Piroxicam and Warfarin?
Piroxicam is an anti-inflammatory drug that can increase the risk of bleeding when taken with blood thinners like warfarin. This combination makes it more likely for you to experience serious bleeding issues.
Warfarin carries more major-labeled pairs than Piroxicam
SPL source-record counts only. This page's band is moderate · classes on file: Piroxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Warfarin (Vitamin K Antagonist (Anticoagulant)).
Warfarin has 2 major-labeled pairs vs Piroxicam's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 11 minor · 15 total
- Other moderate peers for Piroxicam
- Furosemide
- Methotrexate
- Diflunisal
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Diclofenac
- Desvenlafaxine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.