Piroxicam and Methotrexate Interaction
Drug interaction information between Piroxicam and Methotrexate.
Piroxicam and Methotrexate have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Piroxicam and Methotrexate. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Piroxicam can cause methotrexate to build up to toxic levels in your blood, which can harm your kidneys and blood health.
FDA Label Information
Methotrexate Clinical Impact: Concomitant use of NSAIDs and methotrexate may increase the risk for methotrexate toxicity (e.g., neutropenia, thrombocytopenia, renal dysfunction). Intervention: During concomitant use of piroxicam capsules and methotrexate, monitor patients for methotrexate toxicity.
Piroxicam Also Interacts With
- Furosemide moderate
- Diflunisal moderate
- Warfarin moderate
- Meloxicam minor
- Aspirin minor
Methotrexate Also Interacts With
- Celecoxib moderate
- Diflunisal moderate
- Indomethacin moderate
- Mefenamic Acid moderate
- Meloxicam moderate
Frequently Asked Questions
What SPL severity band is on file for Piroxicam + Methotrexate?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Methotrexate has 38 labeled pairs on file vs Piroxicam's 15. In the moderate band specifically: Piroxicam has 4 (also Furosemide, Diflunisal, Warfarin); Methotrexate has 12 (also Celecoxib, Diflunisal, Indomethacin, Mefenamic Acid).
What mechanism field is on file for Piroxicam and Methotrexate?
Piroxicam can cause methotrexate to build up to toxic levels in your blood, which can harm your kidneys and blood health.
Methotrexate's labeled portfolio outnumbers Piroxicam
SPL source-record counts only. This page's band is moderate · classes on file: Piroxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Methotrexate (Disease-Modifying Antirheumatic Drug (DMARD)).
0 major · 4 moderate · 11 minor · 15 total
- Other moderate peers for Piroxicam
- Furosemide
- Diflunisal
- Warfarin
0 major · 12 moderate · 26 minor · 38 total
- Other moderate peers for Methotrexate
- Celecoxib
- Diflunisal
- Indomethacin
- Mefenamic Acid
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.