What the FDA labels say about taking them together
Furosemide and piroxicam
Piroxicam's FDA label of August 19, 2026 names furosemide in its drug interactions section; furosemide's label does not name piroxicam itself but warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)). The piroxicam label: “Clinical studies, as well as postmarketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. …”
Check it at the source: the furosemide FDA label on DailyMed (effective September 30, 2025, Validus Pharmaceuticals LLC); the piroxicam FDA label on DailyMed (effective August 19, 2026, Teva Pharmaceuticals USA, Inc.).
What does the furosemide label say about piroxicam?
Furosemide's label does not name piroxicam itself; it warns about its class (NSAIDs (nonsteroidal anti-inflammatory drugs)):
Furosemide label, drug interactionsThere are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in conjunction with NSAIDs.
Source: FDA drug label (Lasix), Validus Pharmaceuticals LLC, effective September 30, 2025 (SPL set 2c9b4d8f-0770-482d-a9e6-9c616a440b1a), via openFDA; the full label on DailyMed
What does the piroxicam label say about furosemide?
Piroxicam label, drug interactionsDiuretics Clinical Impact: Clinical studies, as well as postmarketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. This effect has been attributed to the NSAID inhibition of renal prostaglandin synthesis. Intervention: During concomitant use of piroxicam with diuretics, observe patients for signs of worsening renal function, in addition to assuring diuretic efficacy including antihypertensive effects [see Warnings and Precautions ()].
Source: FDA drug label (Piroxicam), Teva Pharmaceuticals USA, Inc., effective August 19, 2026 (SPL set f1123fe1-b79c-430b-8548-08cd6e518482), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Furosemide | Piroxicam | |
|---|---|---|
| Labeled for | Heart failure, High blood pressure, Edema (fluid retention) | Osteoarthritis, Rheumatoid arthritis |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $0.490 per mL 20 mg/2 mL vial | $0.215 per capsule 20 mg capsule |
| Shortage now | In shortage | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once