Piroxicam and Furosemide Interaction
Drug interaction information between Piroxicam and Furosemide.
Piroxicam and Furosemide have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Piroxicam and Furosemide. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Piroxicam can make your water pill less effective at removing salt and fluid from your body.
FDA Label Information
Diuretics Clinical Impact: Clinical studies, as well as post-marketing observations, showed that NSAIDs reduced the natriuretic effect of loop diuretics (e.g., furosemide) and thiazide diuretics in some patients. In such high risk patients, monitor for signs of worsening renal function ( 7 ) • Diuretics : NSAIDs can reduce natriuretic effect of furosemide and thiazide diuretics.
Piroxicam Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Meloxicam minor
- Aspirin minor
Furosemide Also Interacts With
- Dutasteride major
- Dutasteride/Tamsulosin major
- Tamsulosin major
- Cyclosporine moderate
- Lithium moderate
Frequently Asked Questions
What SPL severity band is on file for Piroxicam + Furosemide?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Furosemide has 36 labeled pairs on file vs Piroxicam's 15. In the moderate band specifically: Piroxicam has 4 (also Methotrexate, Diflunisal, Warfarin); Furosemide has 4 (also Cyclosporine, Lithium, Oxaprozin).
What mechanism field is on file for Piroxicam and Furosemide?
Piroxicam can make your water pill less effective at removing salt and fluid from your body.
Furosemide carries more major-labeled pairs than Piroxicam
SPL source-record counts only. This page's band is moderate · classes on file: Piroxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Furosemide (Loop Diuretic).
Furosemide has 3 major-labeled pairs vs Piroxicam's 0. This page itself is in the moderate band, not the major band.
0 major · 4 moderate · 11 minor · 15 total
- Other moderate peers for Piroxicam
- Methotrexate
- Diflunisal
- Warfarin
3 major · 4 moderate · 29 minor · 36 total
- Other moderate peers for Furosemide
- Cyclosporine
- Lithium
- Oxaprozin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.