Piroxicam and Meloxicam Interaction
Drug interaction information between Piroxicam and Meloxicam.
Piroxicam and Meloxicam have a documented minor interaction in FDA labeling.
FDA drug labeling documents a minor-severity interaction between Piroxicam and Meloxicam. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
These are both the same type of pain medicine, and taking them together increases the risk of stomach and kidney damage without providing extra relief.
FDA Label Information
In the absence of data regarding potential interaction between pemetrexed and NSAIDs with longer half-lives (e.g., meloxicam, nabumetone), patients taking these NSAIDs should interrupt dosing for at least five days before, the day of, and two days following pemetrexed administration.
Piroxicam Also Interacts With
- Furosemide moderate
- Methotrexate moderate
- Diflunisal moderate
- Warfarin moderate
- Aspirin minor
Meloxicam Also Interacts With
- Methotrexate moderate
- Diflunisal moderate
- Furosemide minor
- Aspirin minor
- Propranolol minor
Frequently Asked Questions
What SPL severity band is on file for Piroxicam + Meloxicam?
Compiled FDA labeling labels this pair minor. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Meloxicam has 17 labeled pairs on file vs Piroxicam's 15. In the minor band specifically: Piroxicam has 11 (also Aspirin, Propranolol, Diclofenac, Cyclosporine); Meloxicam has 15 (also Furosemide, Aspirin, Propranolol, Warfarin).
What mechanism field is on file for Piroxicam and Meloxicam?
These are both the same type of pain medicine, and taking them together increases the risk of stomach and kidney damage without providing extra relief.
Meloxicam's labeled portfolio outnumbers Piroxicam
SPL source-record counts only. This page's band is minor · classes on file: Piroxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Meloxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 4 moderate · 11 minor · 15 total
- Other minor peers for Piroxicam
- Aspirin
- Propranolol
- Diclofenac
- Cyclosporine
0 major · 2 moderate · 15 minor · 17 total
- Other minor peers for Meloxicam
- Furosemide
- Aspirin
- Propranolol
- Warfarin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.