Piroxicam and Diflunisal Interaction
Drug interaction information between Piroxicam and Diflunisal.
Piroxicam and Diflunisal have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Piroxicam and Diflunisal. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Taking these two similar pain medicines together increases the risk of serious stomach damage without providing any extra relief.
FDA Label Information
NSAIDs and Salicylates Clinical Impact: Concomitant use of piroxicam with other NSAIDs or salicylates (e.g., diflunisal, salsalate) increases the risk of GI toxicity, with little or no increase in efficacy [see Warnings and Precautions (5.2) ].
Piroxicam Also Interacts With
- Furosemide moderate
- Methotrexate moderate
- Warfarin moderate
- Meloxicam minor
- Aspirin minor
Diflunisal Also Interacts With
- Methotrexate moderate
- Cyclosporine moderate
- Celecoxib moderate
- Indomethacin moderate
- Mefenamic Acid moderate
Frequently Asked Questions
What SPL severity band is on file for Piroxicam + Diflunisal?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Diflunisal has 17 labeled pairs on file vs Piroxicam's 15. In the moderate band specifically: Piroxicam has 4 (also Furosemide, Methotrexate, Warfarin); Diflunisal has 11 (also Methotrexate, Cyclosporine, Celecoxib, Indomethacin).
What mechanism field is on file for Piroxicam and Diflunisal?
Taking these two similar pain medicines together increases the risk of serious stomach damage without providing any extra relief.
Diflunisal's labeled portfolio outnumbers Piroxicam
SPL source-record counts only. This page's band is moderate · classes on file: Piroxicam (Nonsteroidal Anti-Inflammatory Drug (NSAID)); Diflunisal (Nonsteroidal Anti-Inflammatory Drug (NSAID)).
0 major · 4 moderate · 11 minor · 15 total
- Other moderate peers for Piroxicam
- Furosemide
- Methotrexate
- Warfarin
0 major · 11 moderate · 6 minor · 17 total
- Other moderate peers for Diflunisal
- Methotrexate
- Cyclosporine
- Celecoxib
- Indomethacin
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.