Warfarin and Desvenlafaxine Interaction
Drug interaction information between Warfarin and Desvenlafaxine.
Warfarin and Desvenlafaxine have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Warfarin and Desvenlafaxine. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Desvenlafaxine is an antidepressant that can increase the risk of bleeding when combined with warfarin. It affects how your blood cells work together to stop bleeding.
Warfarin Also Interacts With
- Fluoxetine major
- Tamoxifen major
- Ibuprofen moderate
- Aspirin moderate
- Diclofenac moderate
Desvenlafaxine Also Interacts With
- Aspirin moderate
- Linezolid moderate
- Phenelzine moderate
- Tranylcypromine moderate
- Selegiline moderate
Frequently Asked Questions
What SPL severity band is on file for Warfarin + Desvenlafaxine?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Warfarin has 163 labeled pairs on file vs Desvenlafaxine's 19. In the moderate band specifically: Warfarin has 28 (also Ibuprofen, Aspirin, Diclofenac, Vilazodone); Desvenlafaxine has 6 (also Aspirin, Linezolid, Phenelzine, Tranylcypromine).
What mechanism field is on file for Warfarin and Desvenlafaxine?
Desvenlafaxine is an antidepressant that can increase the risk of bleeding when combined with warfarin. It affects how your blood cells work together to stop bleeding.
Warfarin carries more major-labeled pairs than Desvenlafaxine
SPL source-record counts only. This page's band is moderate · classes on file: Warfarin (Vitamin K Antagonist (Anticoagulant)); Desvenlafaxine (Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)).
Warfarin has 2 major-labeled pairs vs Desvenlafaxine's 0. This page itself is in the moderate band, not the major band.
2 major · 28 moderate · 133 minor · 163 total
- Other moderate peers for Warfarin
- Ibuprofen
- Aspirin
- Diclofenac
- Vilazodone
0 major · 6 moderate · 13 minor · 19 total
- Other moderate peers for Desvenlafaxine
- Aspirin
- Linezolid
- Phenelzine
- Tranylcypromine
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.