Darunavir and Dronedarone Interaction
Drug interaction information between Darunavir and Dronedarone.
Darunavir and Dronedarone have a documented major interaction in FDA labeling.
FDA drug labeling documents a major-severity interaction between Darunavir and Dronedarone. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Darunavir raises the level of dronedarone in your blood by slowing its breakdown. This can cause your heart to beat in a dangerous or irregular way.
FDA Label Information
dronedarone ↑ dronedarone Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as cardiac arrhythmias.
Darunavir Also Interacts With
- Lovastatin major
- Sildenafil major
- Lurasidone major
- Pimozide major
- Midazolam major
Dronedarone Also Interacts With
- Ketoconazole major
- Clarithromycin major
- Voriconazole major
- Ezetimibe major
- Ezetimibe/Simvastatin major
Frequently Asked Questions
What SPL severity band is on file for Darunavir + Dronedarone?
Compiled FDA labeling labels this pair major. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Darunavir has 101 labeled pairs on file vs Dronedarone's 22. In the major band specifically: Darunavir has 15 (also Lovastatin, Sildenafil, Lurasidone, Pimozide); Dronedarone has 9 (also Ketoconazole, Clarithromycin, Voriconazole, Ezetimibe).
What mechanism field is on file for Darunavir and Dronedarone?
Darunavir raises the level of dronedarone in your blood by slowing its breakdown. This can cause your heart to beat in a dangerous or irregular way.
Darunavir carries more major-labeled pairs than Dronedarone
SPL source-record counts only. This page's band is major · classes on file: Darunavir (HIV Protease Inhibitor); Dronedarone (Class III Antiarrhythmic).
Darunavir has 15 major-labeled pairs vs Dronedarone's 9.
15 major · 16 moderate · 70 minor · 101 total
- Other major peers for Darunavir
- Lovastatin
- Sildenafil
- Lurasidone
- Pimozide
9 major · 5 moderate · 8 minor · 22 total
- Other major peers for Dronedarone
- Ketoconazole
- Clarithromycin
- Voriconazole
- Ezetimibe
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.