What the FDA labels say about taking them together
Darunavir and dronedarone
Darunavir's FDA label of August 29, 2025 names dronedarone in its contraindications section; the dronedarone label PlainMeds reads does not name darunavir. The darunavir label: “Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as cardiac arrhythmias.”
Check it at the source: the darunavir FDA label on DailyMed (effective August 29, 2025, Janssen Products LP); the dronedarone FDA label on DailyMed (effective May 29, 2025, Sanofi-Aventis U.S. LLC).
What does the darunavir label say about dronedarone?
Darunavir label, contraindicationsAlpha 1-adrenoreceptor antagonist: alfuzosin Anti-gout: colchicine, in patients with renal and/or hepatic impairment Antimycobacterial: rifampin Antipsychotics: lurasidone, pimozide Cardiac Disorders: dronedarone, ivabradine, ranolazine Ergot derivatives, e.g. dihydroergotamine, ergotamine, methylergonovine Herbal product:
Darunavir label, drug interactionsConcomitant Drug Class Drug Name Examples: dronedarone; Effect on Concentration of Darunavir Or Concomitant Drug: ↑ dronedarone; Clinical Comment: Co-administration is contraindicated due to potential for serious and/or life-threatening reactions such as cardiac arrhythmias.
Source: FDA drug label (PREZISTA), Janssen Products LP, effective August 29, 2025 (SPL set 814301f9-c990-46a5-b481-2879a521a16f), via openFDA; the full label on DailyMed
What does the dronedarone label say about darunavir?
Dronedarone's label (effective May 29, 2025) does not name darunavir in these sections. A label lists what its studies and reports found; it is not a complete list.
Source: FDA drug label (Multaq), Sanofi-Aventis U.S. LLC, effective May 29, 2025 (SPL set 7fa41601-7fb5-4155-8e50-2ae903f0d2d6), via openFDA; the full label on DailyMed
These are the labels' own sentences. PlainMeds does not grade interactions; a pharmacist or prescriber can say what they mean for one person's medicines.
Both medicines on the record
| Darunavir | Dronedarone | |
|---|---|---|
| Labeled for | HIV | n/a |
| Boxed warning | No | Yes |
| Pharmacy cost (NADAC) | $1.16 per tablet 600 mg tablet | $13.19 per tablet 400 mg tablet |
| Shortage now | No current entry | No current entry |
Source: FDA NDC Directory, CMS NADAC of October 7, 2026 and the FDA Drug Shortage Database (FDA files October 8, 2026)
What next?
- Check more medicines together
- up to five at once