indomethacin vs perindopril
Side-by-side comparison of indomethacin and perindopril. Data from FDA drug databases (Orange Book, NDC Directory, recalls, shortages) covering 20,000+ approved drugs, plus CMS pricing; see our methodology.
moderate Known Drug Interaction
Use of potassium-sparing diuretics (spironolactone, amiloride, triamterene and others), potassium supplements or other drugs capable of increasing serum potassium (indomethacin, heparin, cyclosporine and others) can increase the risk of hyperkalemia.
Recommendation: Your doctor may need to adjust your doses and will likely order regular blood tests to check your potassium.
Indocin
Aceon
Indomethacin is a drug that reduces pain and swelling. It belongs to a class of drugs called NSAIDs.
Perindopril (Aceon) is a drug that lowers blood pressure. It can also help reduce the risk of heart problems in people with stable coronary artery disease.
Indomethacin treats moderate to severe rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis. It can also help with acute painful shoulder (bursitis or tendinitis) and gouty arthritis. This medicine reduces pain and swelling in your joints.
Perindopril treats high blood pressure (hypertension). It can be used alone or with other blood pressure medicines. Perindopril also helps lower the risk of heart-related death or heart attack in people who have stable coronary artery disease. It can be used with other treatments for coronary artery disease.
Indomethacin works by blocking substances in the body that cause pain and inflammation. These substances are called prostaglandins. By blocking them, indomethacin helps to reduce swelling, pain, and stiffness.
Perindopril belongs to a class of drugs called ACE inhibitors. It works by relaxing your blood vessels, which lowers blood pressure. This makes it easier for your heart to pump blood.
- • Headache
- • Dizziness
- • Upset stomach
- • Nausea
- • Cough
- • Dizziness
- • Back pain
- Feeling tired 1,102
- Joint pain 1,002
- Head pain 990
- Aches or soreness 921
- Feeling sick to your stomach 907
No adverse event reports.
Indomethacin may increase your risk of serious heart problems like heart attack or stroke, which can be fatal. This risk may occur early in treatment and may increase with longer use. You should not take this medicine before or after heart bypass surgery (CABG). Indomethacin can also increase your risk of serious stomach and intestine problems like bleeding, ulcers, and holes, which can be fatal. These problems can happen without warning. Elderly patients and those with a history of ulcers or GI bleeding are at higher risk.
If you become pregnant, stop taking perindopril right away. This medicine can cause serious harm or death to an unborn baby.
Using indomethacin during the later stages of pregnancy may harm your unborn baby. Limit use between 20 and 30 weeks of pregnancy, and avoid use after 30 weeks. Talk to your doctor if you are pregnant or plan to become pregnant.
Do not take perindopril if you are pregnant. It can cause harm to your unborn baby, especially during the second and third trimesters. It is not known if perindopril passes into breast milk, so talk to your doctor before breastfeeding.
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How to Read This indomethacin vs perindopril Comparison
indomethacin is classified in the Nonsteroidal Anti-Inflammatory Drug (NSAID) drug class, while perindopril sits within the ACE Inhibitor class. Drugs from different classes work through distinct mechanisms, so a head-to-head comparison illustrates trade-offs rather than equivalence. Both drugs are prescription-only, so a licensed provider must authorize use.
Adverse event totals above are pulled from the FDA's Adverse Event Reporting System (FAERS). For these top-ranked reactions alone, indomethacin has 4,922 submissions while perindopril has 0. Those figures reflect cumulative reporting volume, not per-patient risk, so older, widely dispensed drugs typically look worse on count alone. These two drugs have a known moderate interaction flagged in FDA labeling, attributed to using these medicines at the same time can cause your blood potassium levels to rise too high.. Serious warnings, pregnancy guidance, and contraindications can differ even when indications overlap.
A table cannot substitute for clinical judgment. Effectiveness, tolerability, drug-drug interactions with your other medications, kidney and liver function, pregnancy status, insurance formulary, and price all feed into a decision that only a licensed prescriber can make responsibly. Data here is sourced from FDA Structured Product Labels (SPL) and FAERS, both of which update as manufacturers and clinicians submit new information. This page is for educational purposes only, is not medical advice, and should not be used to self-switch between indomethacin and perindopril - always consult your physician or pharmacist first.
Important: This comparison is for informational purposes only. Drug effects vary between individuals. Always consult your doctor or pharmacist for personalized medical advice.