Paroxetine and Tamsulosin Interaction
Drug interaction information between Paroxetine and Tamsulosin.
Paroxetine and Tamsulosin have a documented moderate interaction in FDA labeling.
FDA drug labeling documents a moderate-severity interaction between Paroxetine and Tamsulosin. This page displays the available source-record category and label text. The category is not an individual risk estimate or medication-combination direction.
How They Interact
Paroxetine stops your body from breaking down tamsulosin normally, which leads to higher levels of the drug in your system. This can increase your risk of having side effects.
FDA Label Information
Tamsulosin hydrochloride capsules should be used with caution in combination with moderate inhibitors of CYP3A4 (e.g., erythromycin), in combination with strong (e.g., paroxetine) or moderate (e.g., terbinafine) inhibitors of CYP2D6, or in patients known to be CYP2D6 poor metabolizers, particularly at a dose higher than 0.4 mg (e.g., 0.8 mg). Concomitant treatment with paroxetine (a strong inhibitor of CYP2D6) resulted in an increase in the C max and AUC of tamsulosin by a factor of 1.3 and 1.6, respectively [see Warnings and Precautions (5.2) and Clinical Pharmacology (12.3)].
Paroxetine Also Interacts With
- Linezolid major
- Pimozide major
- Thioridazine major
- Phenelzine moderate
- Tranylcypromine moderate
Tamsulosin Also Interacts With
- Furosemide major
- Warfarin moderate
- Erythromycin moderate
- Terbinafine moderate
- Dutasteride moderate
Frequently Asked Questions
What SPL severity band is on file for Paroxetine + Tamsulosin?
Compiled FDA labeling labels this pair moderate. That is a source-record field, not an individual medication-combination decision.
Which drug in this pair has the larger labeled-interaction portfolio?
Paroxetine has 51 labeled pairs on file vs Tamsulosin's 18. In the moderate band specifically: Paroxetine has 4 (also Phenelzine, Tranylcypromine, Selegiline); Tamsulosin has 8 (also Warfarin, Erythromycin, Terbinafine, Dutasteride).
What mechanism field is on file for Paroxetine and Tamsulosin?
Paroxetine stops your body from breaking down tamsulosin normally, which leads to higher levels of the drug in your system. This can increase your risk of having side effects.
Paroxetine carries more major-labeled pairs than Tamsulosin
SPL source-record counts only. This page's band is moderate · classes on file: Paroxetine (Selective Serotonin Reuptake Inhibitor (SSRI)); Tamsulosin (Alpha-1 Adrenergic Blocker).
Paroxetine has 3 major-labeled pairs vs Tamsulosin's 1. This page itself is in the moderate band, not the major band.
3 major · 4 moderate · 44 minor · 51 total
- Other moderate peers for Paroxetine
- Phenelzine
- Tranylcypromine
- Selegiline
1 major · 8 moderate · 9 minor · 18 total
- Other moderate peers for Tamsulosin
- Warfarin
- Erythromycin
- Terbinafine
- Dutasteride
Sources: FDA Drug Labels (SPL) via openFDA (2026). This is for informational purposes only and is not medical advice. This registry does not provide individual medication-combination directions.
Read our methodology - how this data is sourced, computed, and verified.